Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study

Gibson, Todd M.; Morton, Lindsay M.; Shiels, Meredith S.; Clarke, Christina A.; Engels, Eric A.

doi:10.1097/QAD.0000000000000428

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study

Published Date:

Sep 24 2014

Publisher's site:

http://dx.doi.org/10.1097/QAD.0000000000000428 New Site Icon

Source:

AIDS. 2014; 28(15):2313-2318.

[PDF-142.22 KB]

Details:

Personal Authors:

Gibson, Todd M. ; Morton, Lindsay M. ; Shiels, Meredith S. ; Clarke, Christina A. ; Engels, Eric A. ;

Keywords:

[+]

Pubmed ID:

25111081

Pubmed Central ID:

PMC4260326

Description:

Objective

HIV-infected people have greatly elevated risk of non-Hodgkin lymphoma (NHL), particularly the AIDS-defining NHL subtypes: diffuse large B-cell lymphoma, Burkitt lymphoma and primary lymphomas arising in the central nervous system. The goals of this analysis were to comprehensively describe risks of NHL subtypes, especially those not well studied, among HIV/AIDS patients; examine risks specifically in the HAART era; and distinguish risks in HIV-infected individuals prior to diagnosis with AIDS.

Design

Population-based registry linkage study.

Methods

We used data from the US HIV/AIDS Cancer Match Study from 1996 to 2010 (N = 273 705) to calculate standardized incidence ratios (SIRs) comparing subtype specific NHL risks in HIV-infected people to those in the general population, and used Poisson regression to test for differences in SIRs between the HIV-only and AIDS periods.

Results

NHL risk was elevated 11-fold compared to the general population, but varied substantially by subtype. AIDS-defining NHL subtypes comprised the majority, and risks were high (SIRs ≥ 17), but risks were also increased for some T-cell lymphomas (SIRs = 3.6–14.2), marginal zone lymphoma (SIR = 2.4), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (SIR = 3.6), and acute lymphoblastic leuke mia/lymphoma (SIR = 2.4).

Conclusion

HIV-infected people in the HAART era continue to have elevated risk of AIDS-defining NHL subtypes, highlighting the contribution of moderate and severe immunosuppression to their cause. Whereas non-AIDS-defining subtypes are much less common, immunosuppression or other dysregulated immune states likely play a role in the cause of some T-cell lymphomas, marginal zone lymphoma, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia, and acute lymphoblastic leukemia/lym phoma.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

5U58DP000812-03/DP/NCCDPHP CDC HHS/United States
5U58DP000824-04/DP/NCCDPHP CDC HHS/United States
5U58DP003875-01/DP/NCCDPHP CDC HHS/United States
5U58DP003931-02/DP/NCCDPHP CDC HHS/United States
HHSN261201000024C/PHS HHS/United States
HHSN261201300021I/PHS HHS/United States
N01PC-2013-00021/PC/NCI NIH HHS/United States
U58 DP000848-04/DP/NCCDPHP CDC HHS/United States
Z99 CA999999/Intramural NIH HHS/United States

Supporting Files:

	nihms-643427.nxml	text/plain
	NIHMS643427-supplement-Supplementary_1.doc	application/msword
	NIHMS643427-supplement-Supplementary_2.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document

No Related Documents.

You May Also Like:

Trends in Primary Central Nervous System Lymphoma Incidence and Survival in the U.S

Personal Author:

Shiels, Meredith S.; Pfeiffer, Ruth M.; Besson, Caroline; Clarke, Christina A.; Morton, Lindsay M.; Nogueira, Leticia; Pawlish, Karen; Yanik, Elizabeth L.; Suneja, Gita; Engels, Eric A.;

Published:

Mar 28 2016

Source:

Br J Haematol. 174(3):417-424.

Description:

It is suspected that primary central nervous system lymphoma (PCNSL) rates are increasing among immunocompetent people. We estimated PCNSL trends in incidence and survival among immunocompetent persons by excluding cases among human immunodeficiency ...

File Type:

[PDF - 527.08 KB]
Excess Mortality among HIV-infected Individuals with Cancer in the United States

Personal Author:

Coghill, Anna E.; Pfeiffer, Ruth M.; Shiels, Meredith S.; Engels, Eric A.;

Published:

Jun 15 2017

Source:

Cancer Epidemiol Biomarkers Prev. 26(7):1027-1033.

Description:

Background : HIV-infected persons are living longer in the era of effective HIV treatment, resulting in an increasing cancer burden in this population. The combined effects of HIV and cancer on mortality are incompletely understood. : Methods : We ex...

File Type:

[PDF - 439.66 KB]
Molecular characteristics of diffuse large B-cell lymphoma in human immunodeficiency virus-infected and -uninfected patients in the pre-highly active antiretroviral therapy and pre-rituximab era

Personal Author:

Morton, Lindsay M.; Kim, Clara J.; Weiss, Lawrence M.; Bhatia, Kishor; Cockburn, Myles; Hawes, Debra; Wang, Sophia S.; Chang, Cindy; Altekruse, Sean F.; Engels, Eric A.; Cozen, Wendy;

Published:

Jul 29 2013

Source:

Leuk Lymphoma. 55(3):551-557.

Description:

Human immunodeficiency virus (HIV) infection substantially elevates diffuse large B-cell lymphoma (DLBCL) risk, but its impact on the distinct DLBCL subtypes defined by cell of origin is unclear. We compared DLBCL molecular characteristics and progno...

File Type:

[PDF - 309.58 KB]
Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States

Personal Author:

Robbins, Hilary A.; Shiels, Meredith S.; Pfeiffer, Ruth M.; Engels, Eric A.;

Published:

Mar 27 2014

Source:

AIDS. 28(6):881-890.

Description:

Objective : HIV-infected people have elevated risk for some cancers. Changing incidence of these cancers over time may reflect changes in three factors: HIV population demographic structure (e.g. age distribution), general population (background) can...

File Type:

[PDF - 498.96 KB]
The Epidemic of Non-Hodgkin Lymphoma in the United States: Disentangling the Effect of HIV, 1992–2009

Personal Author:

Shiels, Meredith S.; Engels, Eric A.; Linet, Martha S.; Clarke, Christina A.; Li, Jianmin; Hall, H. Irene; Hartge, Patricia; Morton, Lindsay M.;

Published:

Apr 17 2013

Source:

Cancer Epidemiol Biomarkers Prev. 22(6):1069-1078.

Description:

Background : For decades, non-Hodgkin lymphoma (NHL) incidence has been increasing worldwide. NHL risk is strongly increased among HIV-infected people. Our understanding of trends in NHL incidence has been hampered by difficulties in separating HIV-i...

File Type:

[PDF - 1.22 MB]