Impact of Multi-Agent Systemic Therapy on All-Cause and Disease-Specific Survival for People Living with HIV Who Are Diagnosed with Non-Hodgkin Lymphoma: Population-based Analyses from the State of Georgia

Details

• Alternative Title:
  Leuk Lymphoma
• Personal Author:
  Lipscomb, Joseph ; Switchenko, Jeffrey M. ; Flowers, Christopher R. ; Gillespie, Theresa W. ; Wortley, Pascale M. ; Bayakly, A. Rana ; Almon, Lyn ; Ward, Kevin C.
• Description:
  For people living with HIV (PLWH) who are subsequently diagnosed with non-Hodgkin lymphoma (NHL), we investigate the impact of standard-of-care (SoC) cancer treatment on all-cause, NHL-specific, and HIV-specific survival outcomes. The focus is on a registry-derived, population-based sample of HIV + adults diagnosed with NHL within 2004-2012 in the state of Georgia. SoC treatment is defined as receipt of multi-agent systemic therapy (MAST). In multivariable survival analyses, SoC cancer treatment is significantly associated with better all-cause and NHL-specific survival, but not better HIV-specific survival across 2004-2017. Having a CD4 count <200 near the time of cancer diagnosis and Ann Arbor stage III/IV disease are associated with worse all-cause and HIV-specific survival; the effects on NHL survival trend negative but are not significant. Future work should expand the geographic base and cancers examined, deepen the level of clinical detail brought to bear, and incorporate the perspectives and recommendations of patients and providers.
• Subjects:
  Adult Antiretroviral Therapy, Highly Active Georgia HIV Infections Humans Lymphoma, AIDS-Related Lymphoma, Non-Hodgkin
• Keywords:
  Competing Risks HIV/AIDS Non-Hodgson Lymphoma Outcomes Research Standard-of-care Therapy Survival Analysis
• Source:
  Leuk Lymphoma. 64(1):151-160
• Pubmed ID:
  36308021
• Pubmed Central ID:
  PMC9905298
• Document Type:
  Journal Article
• Funding:
  HHSN261201800003C/CA/NCI NIH HHSUnited States/ ; P30 AI050409/AI/NIAID NIH HHSUnited States/ ; P30 CA138292/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  64
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a0ccbcd03e6996d203d9fef9409e821ca7aa99bb3b906353196203af873401f8f77b647684d03875146409537db0ae3b2f926ab131c6d753df43cac9006328d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/140161/cdc_140161_DS1.pdf
• File Type:
  [PDF - 368.04 KB ]