i
Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections
-
9 2014
-
-
Source: Int J Infect Dis. 2014; 26:98-102
[PDF-177.26 KB]
Details:
-
Alternative Title:Int J Infect Dis
-
Personal Author:
-
Description:Objectives
Although vitamin D is recognized as an important factor in bone health, its role in osteoarticular infections is unclear. We hypothesized that low vitamin D (25-hydroxycholecalciferol) levels are associated with a lower likelihood of treatment success in osteoarticular infections.
Methods
This was a retrospective cohort study of patients with orthopedic infections who had a 25-hydroxycholecalciferol level drawn when their infection was diagnosed. Outcomes were determined at early (3–6 months) and late (≥6 months) follow-up after completing intravenous antibiotics.
Results
We included 223 patients seen during an 11-month period with osteoarticular infections and baseline 25-hydroxycholecalciferol levels. During the initial inpatient management of the infection, hypovitaminosis D was identified and treated. The mean 25-hydroxycholecalciferol level was 23 ± 14 ng/ml; 167 (75%) patients had levels <30 ng/ml. Overall, infection treatment success was 91% (159/174) at early follow-up and 88% (145/164) at late follow-up. 25-Hydroxycholecalciferol baseline levels were similar in those with and without successful clinical outcomes, both at early (25 ± 15 vs. 21 ± 9 ng/ml; p = 0.3) and late follow-up (25 ± 15 vs. 23 ± 16 ng/ml; p = 0.6).
Conclusions
To our knowledge this is the first report on hypovitaminosis D and its impact on outcomes of osteoarticular infections. Hypovitaminosis D was frequent in this cohort. With vitamin D repletion, there was no difference in treatment success whether patients had baseline hypovitaminosis or not.
-
Subjects:
-
Keywords:
-
Source:
-
Pubmed ID:25025238
-
Pubmed Central ID:PMC4233280
-
Document Type:
-
Funding:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
