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Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections
  • Published Date:
    Jul 12 2014
  • Source:
    Int J Infect Dis. 2014; 26:98-102.
Filetype[PDF-177.26 KB]

  • Pubmed ID:
  • Pubmed Central ID:
  • Description:

    Although vitamin D is recognized as an important factor in bone health, its role in osteoarticular infections is unclear. We hypothesized that low vitamin D (25-hydroxycholecalciferol) levels are associated with a lower likelihood of treatment success in osteoarticular infections.


    This was a retrospective cohort study of patients with orthopedic infections who had a 25-hydroxycholecalciferol level drawn when their infection was diagnosed. Outcomes were determined at early (3–6 months) and late (≥6 months) follow-up after completing intravenous antibiotics.


    We included 223 patients seen during an 11-month period with osteoarticular infections and baseline 25-hydroxycholecalciferol levels. During the initial inpatient management of the infection, hypovitaminosis D was identified and treated. The mean 25-hydroxycholecalciferol level was 23 ± 14 ng/ml; 167 (75%) patients had levels <30 ng/ml. Overall, infection treatment success was 91% (159/174) at early follow-up and 88% (145/164) at late follow-up. 25-Hydroxycholecalciferol baseline levels were similar in those with and without successful clinical outcomes, both at early (25 ± 15 vs. 21 ± 9 ng/ml; p = 0.3) and late follow-up (25 ± 15 vs. 23 ± 16 ng/ml; p = 0.6).


    To our knowledge this is the first report on hypovitaminosis D and its impact on outcomes of osteoarticular infections. Hypovitaminosis D was frequent in this cohort. With vitamin D repletion, there was no difference in treatment success whether patients had baseline hypovitaminosis or not.

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  • Funding:
    K12 RR023249/RR/NCRR NIH HHS/United States
    UL1 RR024992/RR/NCRR NIH HHS/United States
    K12 HD001459/HD/NICHD NIH HHS/United States
    UL1 TR000448/TR/NCATS NIH HHS/United States
    U54 CK000162/CK/NCEZID CDC HHS/United States
    KL2 RR024994/RR/NCRR NIH HHS/United States
    5K12HD001459-13/HD/NICHD NIH HHS/United States
    KL2 TR000450/TR/NCATS NIH HHS/United States
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