Low maternal 25-hydroxyvitamin D concentration increases the risk of severe and mild preeclampsia

Details

• Alternative Title:
  Ann Epidemiol
• Personal Author:
  Baca, Katharyn M. ; Simhan, Hyagriv N. ; Platt, Robert W. ; Bodnar, Lisa M.
• Description:
  Purpose:
  
  The objective of this case-cohort study was to evaluate the relationship between maternal 25-hydroxyvitamin D (25(OH)D) concentration and preeclampsia overall and by severity.
  
  Methods:
  
  From an eligible cohort of 12,861 women who had serum banked from aneuploidy screening in Pittsburgh, Pennsylvania from 1999 to 2010, we randomly sampled a subcohort of 2327 pregnancies and all remaining preeclampsia cases (n = 650 cases). Preeclampsia (defined as new-onset hypertension and proteinuria) and its mild and severe forms were identified using ICD-9 codes. Maternal serum collected at 20 weeks or less gestation was measured for 25(OH)D. We used log-binomial regression with restricted cubic splines to estimate the association between 25(OH)D and preeclampsia after adjusting for confounders.
  
  Results:
  
  Approximately 21% of the randomly selected sample had 25(OH)D less than 50 nmol per L. We found that the adjusted risk of preeclampsia declined as serum 25(OH)D increased to 50 nmol per L and then plateaued (test of nonlinearity P < .05). The adjusted preeclampsia risk ratios (95% confidence intervals) for 25(OH)D less than 25 nmol per L, 25 to 49.9 nmol per L, and 50 to 74.9 nmol per L were 2.4 (1.2–4.8), 1.1 (0.69–1.7), and 1.3 (0.89–1.8), respectively, compared with those with 25(OH)D 75 nmol per L and over. Similar associations were observed with severe and mild preeclampsia.
  
  Conclusions:
  
  Vitamin D deficiency increases risks of severe and mild forms of preeclampsia.
  
  
• Subjects:
  Adult Biomarkers Case-Control Studies Female Humans Multivariate Analysis Pre-Eclampsia Pregnancy Regression Analysis Risk Factors Severity Of Illness Index Vitamin D Vitamin D Deficiency

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• Keywords:
  25-Hydroxyvitamin D Hypertension Preeclampsia Vitamin D Deficiency
• Source:
  Ann Epidemiol. 26(12):853-857.e1
• Pubmed ID:
  27818017
• Pubmed Central ID:
  PMC7848792
• Document Type:
  Journal Article
• Funding:
  U01 DP003177/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  26
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2848e3fee4a5120f68b7d4eb3a5fa835e6664db250536b955b82788680985ee7
• Download URL:
  https://stacks.cdc.gov/view/cdc/153683/cdc_153683_DS1.pdf
• File Type:
  [PDF - 179.91 KB ]