Associations of dietary folate, vitamin B6, B12 and methionine intake with risk of breast cancer among African American (AA) and European American (EA) women

Details

• Alternative Title:
  Int J Cancer
• Personal Author:
  Gong, Zhihong ; Ambrosone, Christine B. ; McCann, Susan E. ; Zirpoli, Gary ; Chandran, Urmila ; Hong, Chi-Chen ; Bovbjerg, Dana H. ; Jandorf, Lina ; Ciupak, Gregory ; Pawlish, Karen ; Lu, Quanjun ; Hwang, Helena ; Khoury, Thaer ; Wiam, Bshara ; Bandera, Elisa V.
• Description:
  African American (AA) women are more likely than European American (EA) women to be diagnosed with breast cancer at younger ages and to develop poor prognosis tumors. However, these racial differences are largely unexplained. Folate and other methyl-group nutrients may be related to breast carcinogenesis, but few studies have examined these associations in AA populations. We examined the associations of dietary intake of these nutrients with breast cancer risk overall, by menopausal and estrogen receptor (ER) status among 1,582 AA (749 cases) and 1,434 EA (744 cases) women using data from a case-control study, the Women's Circle of Health Study. Unconditional multivariable logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for the association of each nutrient and breast cancer risk. In AA women, inverse associations were observed for natural food folate intake among premenopausal women (fourth vs. first quartile: OR = 0.57, 95% CI, 0.33-1.00; p for trend = 0.06) and for ER-positive tumors (fourth vs. first quartile: OR = 0.58, 95% CI, 0.36-0.93; p for trend = 0.03), whereas in EA women, a positive association was observed for intake of synthetic folate (fourth vs. first quartile: OR = 1.53, 95% CI, 1.06-2.21; p for trend = 0.03). Our findings suggest that natural food folate intake is inversely associated with breast cancer risk and that this association may vary by race, menopausal status or ER status. The finding of an increased risk observed among EA women with the highest intake of synthetic folate from fortified foods warrants further investigation.
• Subjects:
  Adolescent Adult Black Or African American Breast Neoplasms Case-Control Studies Diet Female Folic Acid Follow-Up Studies Genetic Predisposition To Disease Humans Methionine Middle Aged Neoplasm Staging Premenopause Prognosis Receptors, Estrogen Receptors, Progesterone Risk Factors Vitamin B 6 Vitamin B 12 Vitamins White People Young Adult

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• Keywords:
  African American Breast Cancer Diet European American Folate One-carbon Nutrients
• Source:
  Int J Cancer. 134(6):1422-1435
• Pubmed ID:
  23996837
• Pubmed Central ID:
  PMC4161208
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA072720/CA/NCI NIH HHSUnited States/ ; N01PC-2010-00027/PC/NCI NIH HHSUnited States/ ; 1US58DP003931-01/DP/NCCDPHP CDC HHSUnited States/ ; R01 CA100598/CA/NCI NIH HHSUnited States/ ; P30 CA016056/CA/NCI NIH HHSUnited States/ ; K07 CA178293/CA/NCI NIH HHSUnited States/ ; P01 CA151135/CA/NCI NIH HHSUnited States/ ; K22 CA138563/CA/NCI NIH HHSUnited States/
• Volume:
  134
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3b50c4a2955af91ad90b663ed82bfdeec41b1e0f2a62cfc8f73b7c946da66b31
• Download URL:
  https://stacks.cdc.gov/view/cdc/30112/cdc_30112_DS1.pdf
• File Type:
  [PDF - 608.97 KB ]