One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects
Published Date:Feb 15 2014
Source:Birth Defects Res A Clin Mol Teratol. 100(2):107-115.
Pubmed Central ID:PMC4156397
Funding:HD039054/HD/NICHD NIH HHS/United States
HL077708/HL/NHLBI NIH HHS/United States
HL085859/HL/NHLBI NIH HHS/United States
R01 HD039054/HD/NICHD NIH HHS/United States
R01 HL077708/HL/NHLBI NIH HHS/United States
R01 HL085859/HL/NHLBI NIH HHS/United States
U01DD000489/DD/NCBDD CDC HHS/United States
Evidence exists for an association between use of vitamin supplements with folic acid in early pregnancy and reduced risk for offspring with conotruncal heart defects. A few observations have been made about nutrients related to one-carbon metabolism other than folate. Our prospective study attempted to extend information on nutrition and conotruncal heart defects by measuring analytes in mid-pregnancy sera.
This study included data from a repository of women’s mid-pregnancy serum specimens based on screened pregnancies in California from 2002–07. Each woman’s specimen was linked with delivery information to determine whether her fetus had a conotruncal heart defect or another structural malformation, or was nonmalformed. We identified 140 conotruncal cases and randomly selected 280 specimens as nonmalformed controls. Specimens were tested for a variety of analytes including: homocysteine, methylmalonic acid, folate, vitamin B12, pyridoxal phosphate, pyridoxal, pyridoxic acid, riboflavin, total choline, betaine, methionine, cysteine, cystathionine, arginine, asymmetric and symmetric dimethylarginine.
Results and Conclusions
We did not observe statistical evidence for substantial differences between cases and controls for any of the measured analytes. Analyses specifically targeting B-vitamins also did not reveal differences between cases and controls.
You May Also Like: