Prostate Cancer Risk Profiles in Asian Americans: Disentangling the Effects of Immigration Status and Race/Ethnicity

Details

• Alternative Title:
  J Urol
• Personal Author:
  Lichtensztajn, Daphne Y. ; Gomez, Scarlett Lin ; Sieh, Weiva ; Chung, Benjamin I. ; Cheng, Iona ; Brooks, James D.
• Description:
  Purpose ; Asian-American men with prostate cancer have been reported to present with higher grade and later stage disease than White Americans. However, Asian Americans comprise a heterogeneous population with distinct health outcomes. We compared prostate cancer risk profiles among the diverse racial and ethnic groups in California. ; Materials and Methods ; We used data from the California Cancer Registry for 90,845 Non-Hispanic White, Non-Hispanic Black, and Asian-American men diagnosed with prostate cancer between 2004 and 2010. Patients were categorized into low, intermediate, or high-risk groups based on clinical stage, Gleason score, and PSA value at diagnosis. Using polytomous logistic regression, we estimated adjusted odds ratios for the association of race/ethnicity and nativity with risk group. ; Results ; In addition to Non-Hispanic Blacks, six Asian-American groups (US-born Chinese, foreign-born Chinese, US-born Japanese, foreign-born Japanese, foreign-born Filipino, and foreign-born Vietnamese) were more likely to have an unfavorable risk profile compared to Non-Hispanic Whites. The odds ratios for high vs. intermediate-risk disease ranged from 1.23 (95% CI, 1.02–1.49) for US-born Japanese to 1.45 (95% CI, 1.31–1.60) for foreign-born Filipinos. These associations appeared to be driven by higher grade and PSA values, rather than advanced clinical stage at diagnosis. ; Conclusions ; In this large, ethnically diverse population-based cohort, we found that Asian-American men were more likely to have unfavorable risk profiles at diagnosis. This association varied by racial/ethnic group and nativity, and was not attributable to later stage at diagnosis, suggesting that Asian men may have biological differences that predispose to the development of more severe disease.
• Subjects:
  • Black or African American
  • Asian
  • California
  • Emigration and Immigration
  • Humans
  • Male
  • Prostatic Neoplasms
  • Risk Assessment
  • White People
• Keywords:
  • Asian Americans
  • prostatic neoplasms
  • epidemiology
  • SEER Program
• Source:
  J Urol. 191(4):952-956
• Pubmed ID:
  24513166
• Pubmed Central ID:
  PMC4051432
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; 1U58 DP000807-01/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; K07CA143047/CA/NCI NIH HHSUnited States/ ; K07 CA143047/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/PC/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/
• Volume:
  191
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/29995/cdc_29995_DS1.pdf
• File Type:
  [PDF - 96.72 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4ae55278be042cccd94f6df5b65a13810cdb347b96dc082df54d1aa5431322a7