Nature as a Remarkable Chemist: A Personal Story of the Discovery and Development of Taxol®

Details

• Alternative Title:
  Anticancer Drugs
• Personal Author:
  Wani, Mansukh C. ; Horwitz, Susan Band
• Description:
  The development of a new anticancer drug with a novel structure and unique mechanism of action is an important event, especially when the drug plays a clear role in improving the outcome for cancer patients. No drug fits this description better than Taxol. However, during the early phases of its development, there was little interest in the drug, particularly in the medical community. The story of Taxol is long and fascinating, and includes many examples in which the drug could have been dropped, resulting in its antitumor activity never being available to patients. It was 21 years between the original landmark paper on the isolation and structural determination of Taxol and its approval in 1992 by the FDA for its use in the treatment of ovarian cancer.
• Subjects:
  Antineoplastic Agents, Phytogenic Article Drug Discovery Humans Natural Products Neoplasms Paclitaxel Taxol® Tubulin/Microtubules
• Source:
  Anticancer Drugs. 25(5):482-487.
• Document Type:
  Journal Article
• Funding:
  R01 CA077263/CA/NCI NIH HHS/United States ; SA-43-PH-4322/PH/PHPPO CDC HHS/United States
• Volume:
  25
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6153bf2425a91144ac9c23d9ccbfbdc747632cc6cd324483a606a6b69bbd9bd6
• Download URL:
  https://stacks.cdc.gov/view/cdc/29914/cdc_29914_DS1.pdf
• File Type:
  [PDF - 794.28 KB ]