Rotavirus vaccines

Details

• Alternative Title:
  Hum Vaccin Immunother
• Personal Author:
  Yen, Catherine ; Tate, Jacqueline E ; Hyde, Terri B ; Cortese, Margaret M ; Lopman, Benjamin A ; Jiang, Baoming ; Glass, Roger I ; Parashar, Umesh D
• Description:
  Rotavirus is the leading cause of severe diarrhea among children<5 years worldwide. Currently licensed rotavirus vaccines have been efficacious and effective, with many countries reporting substantial declines in diarrheal and rotavirus-specific morbidity and mortality. However, the full public health impact of these vaccines has not been realized. Most countries, including those with the highest disease burden, have not yet introduced rotavirus vaccines into their national immunization programs. Research activities that may help inform vaccine introduction decisions include (1) establishing effectiveness, impact, and safety for rotavirus vaccines in low-income settings; (2) identifying potential strategies to improve performance of oral rotavirus vaccines in developing countries, such as zinc supplementation; and (3) pursuing alternate approaches to oral vaccines, such as parenteral immunization. Policy- and program-level barriers, such as financial implications of new vaccine introductions, should be addressed to ensure that countries are able to make informed decisions regarding rotavirus vaccine introduction.
• Subjects:
  Diarrhea Drug Discovery Humans Rotavirus Infections Rotavirus Vaccines
• Keywords:
  Diarrhea Gastroenteritis Rotavirus Rotavirus Vaccines Vaccine Impact
• Source:
  Hum Vaccin Immunother. 10(6):1436-1448
• Pubmed ID:
  24755452
• Pubmed Central ID:
  PMC4185955
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  10
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0f4ec1444939dd073040ab255043d27486bbcd898cd004f6102f00e9343e5b2445f941b8418a9308c299cf51035e17a438ea13c820c4fb40deae126a967144f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/37515/cdc_37515_DS1.pdf
• File Type:
  [PDF - 672.94 KB ]