CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Organs-on-chips at the frontiers of drug discovery
-
4 2015
-
Source: Nat Rev Drug Discov. 14(4):248-260
[PDF-456.75 KB]
Details:
-
Alternative Title:Nat Rev Drug Discov
-
Personal Author:
-
Description:Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs - known as organs-on-chips - that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology.
-
Keywords:
-
Source:
-
Pubmed ID:25792263
-
Pubmed Central ID:PMC4826389
-
Document Type:
-
Funding:
-
Volume:14
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
