Organs-on-chips at the frontiers of drug discovery

Details

• Alternative Title:
  Nat Rev Drug Discov
• Personal Author:
  Esch, Eric W. ; Bahinski, Anthony ; Huh, Dongeun
• Description:
  Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs - known as organs-on-chips - that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology.
• Keywords:
  Animals Computer Simulation Drug Discovery Drug Evaluation, Preclinical Drug Industry High-Throughput Screening Assays Humans Models, Biological Pharmacokinetics Rare Diseases
• Source:
  Nat Rev Drug Discov. 14(4):248-260
• Pubmed ID:
  25792263
• Pubmed Central ID:
  PMC4826389
• Document Type:
  Journal Article
• Funding:
  DP2 HL127720/HL/NHLBI NIH HHSUnited States/ ; P30 ES013508/ES/NIEHS NIH HHSUnited States/ ; 1DP2HL127720-01/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  14
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6f3342bed636603f360fc2d51f0584cb21a4e34e66182910959229b68a31c565
• Download URL:
  https://stacks.cdc.gov/view/cdc/38894/cdc_38894_DS1.pdf
• File Type:
  [PDF - 456.75 KB ]