Welcome to CDC stacks | Male breast cancer according to tumor subtype and race: a population based study - 29903 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Male breast cancer according to tumor subtype and race: a population based study
Filetype[PDF-476.60 KB]


Details:
  • Pubmed ID:
    23341341
  • Pubmed Central ID:
    PMC3971835
  • Description:
    Background

    Breast cancer occurs rarely in men. To the best of our knowledge, there are no population-based estimates of the incidence of HER2-neu-positive breast cancer or of the distribution of breast cancer subtypes among male patients. We explored breast tumor subtype distribution by race/ethnicity among men in the large, ethnically diverse population of California.

    Methods

    We included male breast cancer patients diagnosed with invasive breast cancer between 2005-2009 with known ER, PR and HER2-neu status reported to the California Cancer Registry. Among the patients with hormone receptor (HR)-positive tumors, survival probabilities between groups were compared using log-rank tests.

    Results

    Six-hundred and six patients were included. Median age at diagnosis was 68 years. Four hundred and ninety four (81.5%) patients had HR+ tumors, defined as ER+ and/or PR+ and HER2-negative. Ninety (14.9%) had HER2-neu-positive, and 22 (3.6%) had triple receptor-negative tumors (TN). Among HR+ patients, Non-Hispanic Blacks and Hispanics were more likely to have PR negative tumors compared to Non-Hispanic Whites. There was a borderline statistically significant difference in survival according to tumor subtype (p=0.088). Differences in survival according to race/ethnicity were seen among all patients (p=0.087) and among those with HR+ tumors (p=0.0170), with Non-Hispanic Blacks having poorer outcomes.

    Conclusions

    In this large, representative cohort of male breast cancer patients, the distribution of tumor subtypes was different from that reported for females and varied by race/ethnicity. Non-Hispanic Blacks were more likely to have triple receptor-negative tumors and more likely to have ER+/PR- tumors than white men.

  • Document Type:
  • Collection(s):
  • Funding:
    1U58DP00807-01/DP/NCCDPHP CDC HHS/United States
    2P30 CA016672/CA/NCI NIH HHS/United States
    HHSN261201000040C/PHS HHS/United States
    N01-PC-35,139/PC/NCI NIH HHS/United States
    N01-PC-54,404/PC/NCI NIH HHS/United States
    P30 CA016672/CA/NCI NIH HHS/United States
    R01-CA121052/CA/NCI NIH HHS/United States
    R01-ES015552/ES/NIEHS NIH HHS/United States
No Related Documents.
You May Also Like: