Male breast cancer according to tumor subtype and race: a population based study
Published Date:Jan 22 2013
Pubmed Central ID:PMC3971835
Funding:1U58DP00807-01/DP/NCCDPHP CDC HHS/United States
2P30 CA016672/CA/NCI NIH HHS/United States
HHSN261201000040C/PHS HHS/United States
N01-PC-35,139/PC/NCI NIH HHS/United States
N01-PC-54,404/PC/NCI NIH HHS/United States
P30 CA016672/CA/NCI NIH HHS/United States
R01-CA121052/CA/NCI NIH HHS/United States
R01-ES015552/ES/NIEHS NIH HHS/United States
Breast cancer occurs rarely in men. To the best of our knowledge, there are no population-based estimates of the incidence of HER2-neu-positive breast cancer or of the distribution of breast cancer subtypes among male patients. We explored breast tumor subtype distribution by race/ethnicity among men in the large, ethnically diverse population of California.
We included male breast cancer patients diagnosed with invasive breast cancer between 2005-2009 with known ER, PR and HER2-neu status reported to the California Cancer Registry. Among the patients with hormone receptor (HR)-positive tumors, survival probabilities between groups were compared using log-rank tests.
Six-hundred and six patients were included. Median age at diagnosis was 68 years. Four hundred and ninety four (81.5%) patients had HR+ tumors, defined as ER+ and/or PR+ and HER2-negative. Ninety (14.9%) had HER2-neu-positive, and 22 (3.6%) had triple receptor-negative tumors (TN). Among HR+ patients, Non-Hispanic Blacks and Hispanics were more likely to have PR negative tumors compared to Non-Hispanic Whites. There was a borderline statistically significant difference in survival according to tumor subtype (p=0.088). Differences in survival according to race/ethnicity were seen among all patients (p=0.087) and among those with HR+ tumors (p=0.0170), with Non-Hispanic Blacks having poorer outcomes.
In this large, representative cohort of male breast cancer patients, the distribution of tumor subtypes was different from that reported for females and varied by race/ethnicity. Non-Hispanic Blacks were more likely to have triple receptor-negative tumors and more likely to have ER+/PR- tumors than white men.
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