Male breast cancer according to tumor subtype and race: a population based study

Details

• Alternative Title:
  Cancer
• Personal Author:
  Chavez-MacGregor, Mariana ; Clarke, Christina A. ; Lichtensztajn, Daphne ; Hortobagyi, Gabriel N. ; Giordano, Sharon H.
• Description:
  Background ; Breast cancer occurs rarely in men. To the best of our knowledge, there are no population-based estimates of the incidence of HER2-neu-positive breast cancer or of the distribution of breast cancer subtypes among male patients. We explored breast tumor subtype distribution by race/ethnicity among men in the large, ethnically diverse population of California. ; Methods ; We included male breast cancer patients diagnosed with invasive breast cancer between 2005-2009 with known ER, PR and HER2-neu status reported to the California Cancer Registry. Among the patients with hormone receptor (HR)-positive tumors, survival probabilities between groups were compared using log-rank tests. ; Results ; Six-hundred and six patients were included. Median age at diagnosis was 68 years. Four hundred and ninety four (81.5%) patients had HR+ tumors, defined as ER+ and/or PR+ and HER2-negative. Ninety (14.9%) had HER2-neu-positive, and 22 (3.6%) had triple receptor-negative tumors (TN). Among HR+ patients, Non-Hispanic Blacks and Hispanics were more likely to have PR negative tumors compared to Non-Hispanic Whites. There was a borderline statistically significant difference in survival according to tumor subtype (p=0.088). Differences in survival according to race/ethnicity were seen among all patients (p=0.087) and among those with HR+ tumors (p=0.0170), with Non-Hispanic Blacks having poorer outcomes. ; Conclusions ; In this large, representative cohort of male breast cancer patients, the distribution of tumor subtypes was different from that reported for females and varied by race/ethnicity. Non-Hispanic Blacks were more likely to have triple receptor-negative tumors and more likely to have ER+/PR- tumors than white men.
• Subjects:
  • Aged
  • Breast Neoplasms, Male
  • Racial Groups
  • Genes, erbB-2
  • Humans
  • Male
  • Population Surveillance
  • Receptors, Estrogen
  • Receptors, Progesterone
• Source:
  Cancer. 119(9):1611-1617.
• Pubmed ID:
  23341341
• Pubmed Central ID:
  PMC3971835
• Document Type:
  Journal Article
• Funding:
  1U58DP00807-01/DP/NCCDPHP CDC HHS/United States ; 2P30 CA016672/CA/NCI NIH HHS/United States ; HHSN261201000040C/PHS HHS/United States ; N01-PC-35,139/PC/NCI NIH HHS/United States ; N01-PC-54,404/PC/NCI NIH HHS/United States ; P30 CA016672/CA/NCI NIH HHS/United States ; R01-CA121052/CA/NCI NIH HHS/United States ; R01-ES015552/ES/NIEHS NIH HHS/United States
• Place as Subject:
  California
• Volume:
  119
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/29903/cdc_29903_DS1.pdf
• File Type:
  [PDF - 476.60 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1119b92de17e594a3116de691720393fe97d19e34d0b165b78c29a6d029be20e