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MicroRNA-128 governs neuronal excitability and motor behavior in mice
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Dec 6 2013
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Source: Science. 342(6163):1254-1258.
[PDF-780.67 KB]
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Alternative Title:Science
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Description:The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders.
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Pubmed ID:24311694
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Pubmed Central ID:PMC3932786
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Volume:342
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Issue:6163
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