Details:

Alternative Title:
Science
Publisher's site:
http://dx.doi.org/10.1126/science.1244193
Personal Author:
Tan, Chan Lek ; Plotkin, Joshua L. ; Venø, Morten T. ; von Schimmelmann, Melanie ; Feinberg, Philip ; ... More +
Tan, Chan Lek ; Plotkin, Joshua L. ; Venø, Morten T. ; von Schimmelmann, Melanie ; Feinberg, Philip ; Mann, Silas ; Handler, Annie ; Kjems, Jørgen ; Surmeier, D. James ; O’Carroll, Dónal ; Greengard, Paul ; Schaefer, Anne Less -
Description:
The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders.
Subject:
[+]
Animals
Article
Corpus Striatum
Dendrites
Epilepsy
Hyperkinesis
MAP Kinase Signaling System
Mice
MicroRNAs
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Motor Activity
Neurons
Parkinsonian Disorders
Prosencephalon
RNA, Messenger
RNA-Induced Silencing Complex
Up-Regulation

Source:
Science. 342(6163):1254-1258.
Pubmed ID:
24311694
Pubmed Central ID:
PMC3932786
Document Type:
Journal Article
Funding:
1DP2MH100012-01/DP/NCCDPHP CDC HHS/United States ; DA025962/DA/NIDA NIH HHS/United States ; DA10044/DA/NIDA NIH HHS/United States ; DP2 MH100012/MH/NIMH NIH HHS/United States ; NS34696/NS/NINDS NIH HHS/United States ; ... More +
1DP2MH100012-01/DP/NCCDPHP CDC HHS/United States ; DA025962/DA/NIDA NIH HHS/United States ; DA10044/DA/NIDA NIH HHS/United States ; DP2 MH100012/MH/NIMH NIH HHS/United States ; NS34696/NS/NINDS NIH HHS/United States ; P01 DA010044/DA/NIDA NIH HHS/United States ; P50 MH090963/MH/NIMH NIH HHS/United States ; P50MH090963/MH/NIMH NIH HHS/United States ; R01 NS034696/NS/NINDS NIH HHS/United States ; R03 DA025962/DA/NIDA NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:5386bd91a6941e4e5611364398de389e892a2637458edd68b3495cc7296f45ef
File Type:

Supporting Files

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  	NIHMS554436-supplement-Supplementary_material.pdf	pdf
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