MicroRNA-128 governs neuronal excitability and motor behavior in mice

Details

• Alternative Title:
  Science
• Personal Author:
  Tan, Chan Lek ; Plotkin, Joshua L. ; Venø, Morten T. ; von Schimmelmann, Melanie ; Feinberg, Philip ; Mann, Silas ; Handler, Annie ; Kjems, Jørgen ; Surmeier, D. James ; O’Carroll, Dónal ; Greengard, Paul ; Schaefer, Anne
• Description:
  The control of motor behavior in animals and humans requires constant adaptation of neuronal networks to signals of various types and strengths. We found that microRNA-128 (miR-128), which is expressed in adult neurons, regulates motor behavior by modulating neuronal signaling networks and excitability. miR-128 governs motor activity by suppressing the expression of various ion channels and signaling components of the extracellular signal-regulated kinase ERK2 network that regulate neuronal excitability. In mice, a reduction of miR-128 expression in postnatal neurons causes increased motor activity and fatal epilepsy. Overexpression of miR-128 attenuates neuronal responsiveness, suppresses motor activity, and alleviates motor abnormalities associated with Parkinson's-like disease and seizures in mice. These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders.
• Subjects:
  Animals Article Corpus Striatum Dendrites Epilepsy Hyperkinesis MAP Kinase Signaling System Mice MicroRNAs Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Motor Activity Neurons Parkinsonian Disorders Prosencephalon RNA, Messenger RNA-Induced Silencing Complex Up-Regulation

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• Source:
  Science. 342(6163):1254-1258.
• Pubmed ID:
  24311694
• Pubmed Central ID:
  PMC3932786
• Document Type:
  Journal Article
• Funding:
  1DP2MH100012-01/DP/NCCDPHP CDC HHS/United States ; DA025962/DA/NIDA NIH HHS/United States ; DA10044/DA/NIDA NIH HHS/United States ; DP2 MH100012/MH/NIMH NIH HHS/United States ; NS34696/NS/NINDS NIH HHS/United States ; P01 DA010044/DA/NIDA NIH HHS/United States ; P50 MH090963/MH/NIMH NIH HHS/United States ; P50MH090963/MH/NIMH NIH HHS/United States ; R01 NS034696/NS/NINDS NIH HHS/United States ; R03 DA025962/DA/NIDA NIH HHS/United States
• Volume:
  342
• Issue:
  6163
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5386bd91a6941e4e5611364398de389e892a2637458edd68b3495cc7296f45ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/29855/cdc_29855_DS1.pdf
• File Type:
  [PDF - 780.67 KB ]