Details:

Alternative Title:
Phys Rev Lett
Personal Author:
Wang, Lidai ; Xia, Jun ; Yao, Junjie ; Maslov, Konstantin I. ; Wang, Lihong V.
Wang, Lidai ; Xia, Jun ; Yao, Junjie ; Maslov, Konstantin I. ; Wang, Lihong V. Less -
Description:
Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded photoacoustic flowgraphy combining ultrasonic thermal tagging with photoacoustic imaging. Focused ultrasound generates a confined heat source in acoustically absorptive fluid. Thermal waves propagate with the flow and are directly visualized in pseudo color using photoacoustic computed tomography. The Doppler shift is employed to calculate the flow speed. This method requires only acoustic and optical absorption, and thus is applicable to continuous fluid. A blood flow speed as low as 0.24  mm·s(-1)} was successfully measured. Deep blood flow imaging was experimentally demonstrated under 5-mm-thick chicken breast tissue.
Subject:
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Article
Blood
Humans
Laser-Doppler Flowmetry
Models, Theoretical
Photoacoustic Techniques
Ultrasonography, Doppler

Source:
Phys Rev Lett. 111(20):204301.
Pubmed ID:
24289689
Pubmed Central ID:
PMC3895050
Document Type:
Journal Article
Funding:
DP1 EB016986/DP/NCCDPHP CDC HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; R01 CA134539/CA/NCI NIH HHS/United States ; R01 CA134539/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; ... More +
DP1 EB016986/DP/NCCDPHP CDC HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; R01 CA134539/CA/NCI NIH HHS/United States ; R01 CA134539/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 EB008085/EB/NIBIB NIH HHS/United States ; R01 EB008085/EB/NIBIB NIH HHS/United States ; U54 CA136398/CA/NCI NIH HHS/United States ; U54 CA136398/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e0df7ed5bf88311850ba00fcbe63dd42683ee13fa15b62867a6bd11f450edda9
File Type:

Supporting Files

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