Ultrasonically encoded photoacoustic flowgraphy in biological tissue

Wang, Lidai; Xia, Jun; Yao, Junjie; Maslov, Konstantin I.; Wang, Lihong V.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Ultrasonically encoded photoacoustic flowgraphy in biological tissue

Published Date:

Nov 12 2013

Source:

Phys Rev Lett. 111(20):204301.

[PDF-953.40 KB]

Details:

Personal Authors:

Wang, Lidai ; Xia, Jun ; Yao, Junjie ; Maslov, Konstantin I. ; Wang, Lihong V. ;

Keywords:

[+]

Pubmed ID:

24289689

Pubmed Central ID:

PMC3895050

Description:

Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded photoacoustic flowgraphy combining ultrasonic thermal tagging with photoacoustic imaging. Focused ultrasound generates a confined heat source in acoustically absorptive fluid. Thermal waves propagate with the flow and are directly visualized in pseudo color using photoacoustic computed tomography. The Doppler shift is employed to calculate the flow speed. This method requires only acoustic and optical absorption, and thus is applicable to continuous fluid. A blood flow speed as low as 0.24 mm·s(-1)} was successfully measured. Deep blood flow imaging was experimentally demonstrated under 5-mm-thick chicken breast tissue.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Supporting Files:

	nihms542226f4.gif	image/gif
	nihms542226f4.jpg	image/jpeg
	nihms542226f5.gif	image/gif
	nihms542226f5.jpg	image/jpeg
	NIHMS542226-supplement-Supp__materials.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms542226.nxml	application/octet-stream
	nihms542226f1.gif	image/gif
	nihms542226f1.jpg	image/jpeg
	nihms542226f2.gif	image/gif
	nihms542226f2.jpg	image/jpeg
	nihms542226f3.gif	image/gif
	nihms542226f3.jpg	image/jpeg

No Related Documents.

You May Also Like:

Multi-scale Functional and Molecular Photoacoustic Tomography

Personal Author:

Yao, Junjie; Xia, Jun; Wang, Lihong V.;

Published:

May 01 2015

Source:

Ultrason Imaging. 38(1):44-62.

Description:

Photoacoustic tomography (PAT) combines rich optical absorption contrast with the high spatial resolution of ultrasound at depths in tissue. The high scalability of PAT has enabled anatomical imaging of biological structures ranging from organelles t...

File Type:

[PDF - 1.03 MB]
Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light

Personal Author:

Liu, Yan; Lai, Puxiang; Ma, Cheng; Xu, Xiao; Grabar, Alexander A.; Wang, Lihong V.;

Published:

Jan 05 2015

Source:

Nat Commun. 2015; 6:5904.

Description:

Focusing light deep inside living tissue has not been achieved despite its promise to play a central role in biomedical imaging, optical manipulation and therapy. To address this challenge, internal-guide-star-based wavefront engineering techniques--...

File Type:

[PDF - 1.13 MB]
Ultrasonically encoded wavefront shaping for focusing into random media

Personal Author:

Tay, Jian Wei; Lai, Puxiang; Suzuki, Yuta; Wang, Lihong V.;

Published:

Jan 29 2014

Source:

Sci Rep. 2014; 4.

Description:

Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, scattering can be compensated for by applying a correction to the illumination wavefront using spatial light modulators. One m...

File Type:

[PDF - 589.39 KB]
In vivo optically encoded photoacoustic flowgraphy

Personal Author:

Zhang, Ruiying; Wang, Lidai; Yao, Junjie; Yeh, Cheng-Hung; Wang, Lihong V.;

Published:

Jul 1 2014

Source:

Opt Lett. 2014; 39(13):3814-3817.

Description:

We present an optically encoded photoacoustic (PA) flow imaging method based on optical-resolution PA microscopy. An intensity-modulated continuous-wave laser photothermally encodes the flowing medium, and a pulsed laser generates PA waves to image t...

File Type:

[PDF - 426.23 KB]
Continuous scanning of a time-reversed ultrasonically encoded optical focus by reflection-mode digital phase conjugation

Personal Author:

Suzuki, Yuta; Tay, Jian Wei; Yang, Qiang; Wang, Lihong V.;

Published:

Jun 15 2014

Source:

Opt Lett. 39(12):3441-3444.

Description:

Time-reversed ultrasonically encoded (TRUE) optical focusing in turbid media was previously implemented using both analog and digital phase conjugation. The digital approach, in addition to its large energy gain, can improve the focal intensity and r...

File Type:

[PDF - 803.57 KB]