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Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth
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Published Date:
Jul 15 2013
Source:Opt Lett. 2013; 38(14):2592-2595.Language:English -
Alternative Title:Opt Lett
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Personal Author:
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Description:Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth. To reduce tissue scattering, we propose to use glycerol as an optical clearing agent in OR-PAM. Our results show that the imaging performance of OR-PAM can be greatly enhanced by optical clearing both in vitro and in vivo.
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Subject:
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Pubmed ID:23939121
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Pubmed Central ID:PMC3759812
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