Burden of Human Metapneumovirus Infection in Young Children

Details

• Alternative Title:
  N Engl J Med
• Personal Author:
  Edwards, Kathryn M. ; Zhu, Yuwei ; Griffin, Marie R. ; Weinberg, Geoffrey A. ; Hall, Caroline B. ; Szilagyi, Peter G. ; Staat, Mary A. ; Iwane, Marika ; Prill, Mila M. ; Williams, John V.
• Description:
  BACKGROUND
  
  The inpatient and outpatient burden of human metapneumovirus (HMPV) infection among young children has not been well established.
  
  METHODS
  
  We conducted prospective, population-based surveillance for acute respiratory illness or fever among inpatient and outpatient children less than 5 years of age in three U.S. counties from 2003 through 2009. Clinical and demographic data were obtained from parents and medical records, HMPV was detected by means of a reverse-transcriptase polymerase-chain-reaction assay, and population-based rates of hospitalization and estimated rates of outpatient visits associated with HMPV infection were determined.
  
  RESULTS
  
  HMPV was detected in 200 of 3490 hospitalized children (6%), 222 of 3257 children in outpatient clinics (7%), 224 of 3001 children in the emergency department (7%), and 10 of 770 asymptomatic controls (1%). Overall annual rates of hospitalization associated with HMPV infection were 1 per 1000 children less than 5 years of age, 3 per 1000 infants less than 6 months of age, and 2 per 1000 children 6 to 11 months of age. Children hospitalized with HMPV infection, as compared with those hospitalized without HMPV infection, were older and more likely to receive a diagnosis of pneumonia or asthma, to require supplemental oxygen, and to have a longer stay in the intensive care unit. The estimated annual burden of outpatient visits associated with HMPV infection was 55 clinic visits and 13 emergency department visits per 1000 children. The majority of HMPV-positive inpatient and outpatient children had no underlying medical conditions, although premature birth and asthma were more frequent among hospitalized children with HMPV infection than among those without HMPV infection.
  
  CONCLUSIONS
  
  HMPV infection is associated with a substantial burden of hospitalizations and outpatient visits among children throughout the first 5 years of life, especially during the first year. Most children with HMPV infection were previously healthy. (Funded by the Centers for Disease Control and Prevention and the National Institutes of Health.)
  
  
• Subjects:
  Article Child, Preschool Female Hospitalization Humans Infant Male Metapneumovirus Paramyxoviridae Infections Pneumonia, Viral Population Surveillance Prospective Studies Respiratory Tract Infections

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• Source:
  N Engl J Med. 2013; 368(7):633-643
• Pubmed ID:
  23406028
• Pubmed Central ID:
  PMC3662802
• Document Type:
  Journal Article
• Funding:
  U01 IP000147/IP/NCIRD CDC HHS/United States ; U38/CCU417958/PHS HHS/United States ; U01/IP000147/IP/NCIRD CDC HHS/United States ; R01 AI085062/AI/NIAID NIH HHS/United States ; U38/CCU217969/PHS HHS/United States ; U01/IP000022/IP/NCIRD CDC HHS/United States ; R21 AI082417/AI/NIAID NIH HHS/United States ; U01 IP000022/IP/NCIRD CDC HHS/United States ; U01/IP000017/IP/NCIRD CDC HHS/United States ; U38/CCU522352/PHS HHS/United States ; AI-085062/AI/NIAID NIH HHS/United States ; AI-82417/AI/NIAID NIH HHS/United States ; U01 IP000017/IP/NCIRD CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  368
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:84d664caf0f1d46be492574e4ef9e0d51afb481dac56d6673438c11ca06db0f5
• Download URL:
  https://stacks.cdc.gov/view/cdc/29665/cdc_29665_DS1.pdf
• File Type:
  [PDF - 634.58 KB ]