Association of the Period3 clock gene length polymorphism with salivary cortisol secretion among police officers

Details

• Journal Article:
  Neuro Endocrinol Lett
• Personal Author:
  Wirth, Michael ; Burch, James ; Violanti, John ; Burchfiel, Cecil ; Fekedulegn, Desta ; Andrew, Michael ; Zhang, Hongmei ; Miller, Diane B. ; Youngstedt, Shawn D. ; Hébert, James R. ; Vena, John E.
• Description:
  OBJECTIVE
  
  This study evaluated whether measures of waking or diurnal cortisol secretion, or self-reported psychological disturbances differed among police officers with a Period3 (PER3) clock gene length polymorphism.
  
  METHODS
  
  The cortisol awakening response was characterized via the area under the salivary cortisol curve with respect to the increase (AUCI) or total waking cortisol (AUCG). Diurnal cortisol measures included the slope of diurnal cortisol and the diurnal AUCG. Psychological disturbances were characterized using the Center for Epidemiologic Studies Depression Scale, Impact of Events Scale, and Life Events Scale.
  
  RESULTS
  
  Officers with a 4/5 or 5/5 genotype had higher awakening AUCG and greater diurnal cortisol AUCG levels compared to officers with the 4/4 genotype. Among those working more afternoon or night shifts, waking AUCI and AUCG were greater among officers with a 4/5 or 5/5 genotype compared to the 4/4 referents.
  
  CONCLUSION
  
  Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants.
• Subjects:
  • Article
  • PER3 VNTR
  • circadian
  • cortisol
  • shiftwork
  • police
  • Adult
  • Circadian Rhythm
  • Female
  • Genotype
  More +
• Source:
  Neuro Endocrinol Lett. 2013; 34(1):27-37.
• Pubmed ID:
  23524621
• Pubmed Central ID:
  PMC3655703
• Document Type:
  Text ; Journal Article
• Funding:
  K05 CA136975/CA/NCI NIH HHS/United States ; T32 GM081740/GM/NIGMS NIH HHS/United States ; T32-5R18CE001240/CE/NCIPC CDC HHS/United States
• Genre:
  Journal Article
• Volume:
  34
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/29661/cdc_29661_DS1.pdf
• File Type:
  [PDF - 298.21 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:9b9f50958d9c8d5dd14f837e8bac188b5f76eb5fc7948b6be4253c17f2933965b0391e0bcf69f8e5a4788659b96311d7d0a8e10372d6e8793534726cdb4c3545