Association of the Period3 clock gene length polymorphism with salivary cortisol secretion among police officers

Details

• Personal Author:
  Andrew M ; Burch J ; Burchfiel C ; Fekedulegn D ; Hebert JR ; Miller DB ; Vena JE ; Violanti J ; Wirth M ; Youngstedt SD ; Zhang H
• Description:
  OBJECTIVE: This study evaluated whether measures of waking or diurnal cortisol secretion, or self-reported psychological disturbances differed among police officers with a Period3 (PER3) clock gene length polymorphism. METHODS: The cortisol awakening response was characterized via the area under the salivary cortisol curve with respect to the increase (AUCI) or total waking cortisol (AUCG). Diurnal cortisol measures included the slope of diurnal cortisol and the diurnal AUCG. Psychological disturbances were characterized using the Center for Epidemiologic Studies Depression Scale, Impact of Events Scale, and Life Events Scale. RESULTS: Officers with a 4/5 or 5/5 genotype had higher awakening AUCG and greater diurnal cortisol AUCG levels compared to officers with the 4/4 genotype. Among those working more afternoon or night shifts, waking AUCI and AUCG were greater among officers with a 4/5 or 5/5 genotype compared to the 4/4 referents. CONCLUSION: Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants. [Description provided by NIOSH]
• Subjects:
  Circadian Rhythm Genetics Law Enforcement Occupational Health Safety Sleep Sleep Initiation And Maintenance Disorders
• Keywords:
  Author Keywords: PER3 VNTR BCOPS Biostatistics Circadian Circadian Rhythms Cortisol Genes Genetic Factors Law Enforcement Workers Police Police Officers Shiftwork Shift Workers Sleep Deprivation Work Schedules

  More +
• ISSN:
  0172-780X
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; South Carolina ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  27-37
• Volume:
  34
• Issue:
  1
• NIOSHTIC Number:
  nn:20042589
• Citation:
  Neuro Endocrinol Lett 2013 Feb; 34(1):27-37
• Contact Point Address:
  Michael Wirth, MSPH, PhD., Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Suite 200, Columbia, SC, USA
• Email:
  wirthm@mailbox.sc.edu
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Public Safety
• Peer Reviewed:
  True
• Source Full Name:
  Neuro Endocrinology Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:029a5cbabe90133aa8b47bdc21e63b3c752dc5bbaa0508b347fe77be267dfefc583bfa75412363da1f47776474eea78e264f92466009830267227d7c806d177c
• Download URL:
  https://stacks.cdc.gov/view/cdc/194769/cdc_194769_DS1.pdf
• File Type:
  [PDF - 343.11 KB ]