Association Between Use of Specific Drugs and Antiretroviral Adherence: Findings from MACH 14

Details

• Alternative Title:
  AIDS Behav
• Personal Author:
  Rosen, M. I. ; Black, A. C. ; Arnsten, J. H. ; Goggin, K. ; Remien, R. H. ; Simoni, J. M. ; Golin, C. E. ; Bangsberg, D. R. ; Liu, H.
• Description:
  To determine the association between individual substances of abuse and antiretroviral adherence, analyses require a large sample assessed using electronic data monitoring (EDM). In this analysis, EDM data from 1,636 participants in 12 US adherence-focused studies were analyzed to determine the associations between recent use of various substances and adherence during the preceding 4 weeks. In bivariate analyses comparing adherence among patients who had used a specific substance to those who had not, adherence was significantly lower among those who had recently used cocaine, other stimulants or heroin but not among those who had used cannabis or alcohol. In multivariate analyses controlling for sociodemographics, amount of alcohol use and recent use of any alcohol, cocaine, other stimulants and heroin each was significantly negatively associated with adherence. The significant associations of cocaine, other stimulants, heroin, and alcohol use with adherence suggest that these are important substances to target with adherence-focused interventions.
• Subjects:
  Adult Alcohol-Related Disorders Anti-HIV Agents Data Collection Female HIV Infections Humans Male Medication Adherence Middle Aged Multivariate Analysis Prevalence Socioeconomic Factors Substance-Related Disorders

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• Source:
  AIDS Behav. 17(1):142-147.
• Pubmed ID:
  22246513
• Pubmed Central ID:
  PMC3549004
• Document Type:
  Journal Article
• Funding:
  AI069419/AI/NIAID NIH HHS/United States ; AI38858/AI/NIAID NIH HHS/United States ; CC02-SD-003/CC/ODCDC CDC HHS/United States ; CC99-SD003/CC/ODCDC CDC HHS/United States ; K02DA017277/DA/NIDA NIH HHS/United States ; K23MH01862/MH/NIMH NIH HHS/United States ; P01MH49548/MH/NIMH NIH HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; R01 DA015215/DA/NIDA NIH HHS/United States ; R01 MH054907/MH/NIMH NIH HHS/United States ; R01 MH078773/MH/NIMH NIH HHS/United States ; R01 MH61173/MH/NIMH NIH HHS/United States ; R01AI41413/AI/NIAID NIH HHS/United States ; R01DA015679/DA/NIDA NIH HHS/United States ; R01DA11869/DA/NIDA NIH HHS/United States ; R01DA13826/DA/NIDA NIH HHS/United States ; R01DA15215/DA/NIDA NIH HHS/United States ; R01MH01584/MH/NIMH NIH HHS/United States ; R01MH078773/MH/NIMH NIH HHS/United States ; R01MH54907/MH/NIMH NIH HHS/United States ; R01MH58986/MH/NIMH NIH HHS/United States ; R01MH61695/MH/NIMH NIH HHS/United States ; R01MH68197/MH/NIMH NIH HHS/United States ; R01NR04749/NR/NINR NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  17
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f1147af4df12b09596c0569a1654d6f753c2ebdb55ffede66d2f3c51f906f05c
• Download URL:
  https://stacks.cdc.gov/view/cdc/29617/cdc_29617_DS1.pdf
• File Type:
  [PDF - 208.24 KB ]