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Association Between Use of Specific Drugs and Antiretroviral Adherence: Findings from MACH 14
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  • Description:
    To determine the association between individual substances of abuse and antiretroviral adherence, analyses require a large sample assessed using electronic data monitoring (EDM). In this analysis, EDM data from 1,636 participants in 12 US adherence-focused studies were analyzed to determine the associations between recent use of various substances and adherence during the preceding 4 weeks. In bivariate analyses comparing adherence among patients who had used a specific substance to those who had not, adherence was significantly lower among those who had recently used cocaine, other stimulants or heroin but not among those who had used cannabis or alcohol. In multivariate analyses controlling for sociodemographics, amount of alcohol use and recent use of any alcohol, cocaine, other stimulants and heroin each was significantly negatively associated with adherence. The significant associations of cocaine, other stimulants, heroin, and alcohol use with adherence suggest that these are important substances to target with adherence-focused interventions.

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  • Funding:
    AI069419/AI/NIAID NIH HHS/United States
    AI38858/AI/NIAID NIH HHS/United States
    CC02-SD-003/CC/ODCDC CDC HHS/United States
    CC99-SD003/CC/ODCDC CDC HHS/United States
    K02DA017277/DA/NIDA NIH HHS/United States
    K23MH01862/MH/NIMH NIH HHS/United States
    P01MH49548/MH/NIMH NIH HHS/United States
    R01 DA015215/DA/NIDA NIH HHS/United States
    R01 MH054907/MH/NIMH NIH HHS/United States
    R01 MH078773/MH/NIMH NIH HHS/United States
    R01 MH61173/MH/NIMH NIH HHS/United States
    R01AI41413/AI/NIAID NIH HHS/United States
    R01DA015679/DA/NIDA NIH HHS/United States
    R01DA11869/DA/NIDA NIH HHS/United States
    R01DA13826/DA/NIDA NIH HHS/United States
    R01DA15215/DA/NIDA NIH HHS/United States
    R01MH01584/MH/NIMH NIH HHS/United States
    R01MH078773/MH/NIMH NIH HHS/United States
    R01MH54907/MH/NIMH NIH HHS/United States
    R01MH58986/MH/NIMH NIH HHS/United States
    R01MH61695/MH/NIMH NIH HHS/United States
    R01MH68197/MH/NIMH NIH HHS/United States
    R01NR04749/NR/NINR NIH HHS/United States
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