Discovery and full genome characterization of a new SIV lineage infecting red-tailed guenons (Cercopithecus ascanius schmidti) in Kibale National Park, Uganda

Lauck, Michael; Switzer, William M; Sibley, Samuel D; Hyeroba, David; Tumukunde, Alex; Weny, Geoffrey; Shankar, Anupama; Greene, Justin M; Ericsen, Adam J; Zheng, HaoQiang; Ting, Nelson; Chapman, Colin A; Friedrich, Thomas C; Goldberg, Tony L; O’Connor, David H

doi:10.1186/1742-4690-11-55

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Discovery and full genome characterization of a new SIV lineage infecting red-tailed guenons (Cercopithecus ascanius schmidti) in Kibale National Park, Uganda

Published Date:

Jul 04 2014

Publisher's site:

http://dx.doi.org/10.1186/1742-4690-11-55 New Site Icon

Source:

Retrovirology. 2014; 11:55.

[PDF - 1.30 MB]

Details:

Personal Authors:

Lauck, Michael ; Switzer, William M ; Sibley, Samuel D ; Hyeroba, David ; Tumukunde, Alex ; ... More ▼

Keywords:

[+]

Description:

Background

Human immunodeficiency virus (HIV) type 1 and 2, the causative agents of acquired immunodeficiency syndrome (AIDS), emerged from African non-human primates (NHPs) through zoonotic transmission of simian immunodeficiency viruses (SIV). Among African NHPs, the Cercopithecus genus contains the largest number of species known to harbor SIV. However, our understanding of the diversity and evolution of SIVs infecting this genus is limited by incomplete taxonomic and geographic sampling, particularly in East Africa. In this study, we screened blood specimens from red-tailed guenons (Cercopithecus ascanius schmidti) from Kibale National Park, Uganda, for the presence of novel SIVs using unbiased deep-sequencing.

Findings

We describe and characterize the first full-length SIV genomes from wild red-tailed guenons in Kibale National Park, Uganda. This new virus, tentatively named SIVrtg_Kib, was detected in five out of twelve animals and is highly divergent from other Cercopithecus SIVs as well as from previously identified SIVs infecting red-tailed guenons, thus forming a new SIV lineage.

Conclusions

Our results show that the genetic diversity of SIVs infecting red-tailed guenons is greater than previously appreciated. This diversity could be the result of cross-species transmission between different guenon species or limited gene flow due to geographic separation among guenon populations.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

P51 OD011106/OD/NIH HHS/United States
P51OD011106/OD/NIH HHS/United States
R01 AI077376-04A1/AI/NIAID NIH HHS/United States
R01 AI084787/AI/NIAID NIH HHS/United States
RR000167/RR/NCRR NIH HHS/United States
RR020141-01/RR/NCRR NIH HHS/United States
RR15459-01/RR/NCRR NIH HHS/United States
TW009237/TW/FIC NIH HHS/United States

Supporting Files:

1742-4690-11-55-1.gif	image/gif
1742-4690-11-55-1.jpg	image/jpeg
1742-4690-11-55-2.gif	image/gif
1742-4690-11-55-2.jpg	image/jpeg
1742-4690-11-55-3.gif	image/gif
1742-4690-11-55-3.jpg	image/jpeg
1742-4690-11-55.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Discovery and full genome characterization of two highly divergent simian immunodeficiency viruses infecting black-and-white colobus monkeys (Colobus guereza) in Kibale National Park, Uganda

Personal Author:

Lauck, Michael; Switzer, William M; Sibley, Samuel D; Hyeroba, David; Tumukunde, Alex; Weny, Geoffrey; Taylor, Bill; Shankar, Anupama; Ting, Nelson; Chapman, Colin A; Friedrich, Thomas C; Goldberg, Tony L; O'Connor, David H;

Published:

Oct 21 2013

Source:

Retrovirology. 2013; 10:107.

Description:

Background : African non-human primates (NHPs) are natural hosts for simian immunodeficiency viruses (SIV), the zoonotic transmission of which led to the emergence of HIV-1 and HIV-2. However, our understanding of SIV diversity and evolution is limit...

File Type:

[PDF - 1.45 MB]
Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa

Personal Author:

Mentoor, Juliet L. D.; Lubisi, Alison B.; Gerdes, Truuska; Human, Stacey; Williams, June H.; Venter, Marietjie;

Published:

Jul 28 2016

Source:

Genome Announc. 2016; 4(4).

Description:

We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in huma...

File Type:

[PDF - 142.67 KB]
Detection and Full-Length Genome Characterization of Novel Canine Vesiviruses

Personal Author:

Martella, Vito; Pinto, Pierfrancesco; Lorusso, Eleonora; Di Martino, Barbara; Wang, Qiuhong; Larocca, Vittorio; Cavalli, Alessandra; Camero, Michele; Decaro, Nicola; Bányai, Krisztián; Saif, Linda J.; Buonavoglia, Canio;

Published:

Aug 2015

Source:

Emerg Infect Dis. 21(8):1433-1436.

Description:

Vesiviruses have been detected in several animal species and as accidental contaminants of cells. We detected vesiviruses in asymptomatic kennel dogs (64.8%) and symptomatic (1.1%) and asymptomatic (3.5%) household dogs in Italy. The full-length geno...

File Type:

[PDF - 927.89 KB]
Large-Scale Discovery and Characterization of Protein Regulatory Motifs in Eukaryotes

Personal Author:

Lieber, Daniel S.; Elemento, Olivier; Tavazoie, Saeed;

Published:

Dec 29 2010

Source:

PLoS One. 5(12).

Description:

The increasing ability to generate large-scale, quantitative proteomic data has brought with it the challenge of analyzing such data to discover the sequence elements that underlie systems-level protein behavior. Here we show that short, linear prote...

File Type:

[PDF - 856.95 KB]
Full genome characterization of the first G3P[24] rotavirus strain detected in humans provides evidence of interspecies reassortment and mutational saturation in the VP7 gene

Personal Author:

Mijatovic-Rustempasic, Slavica; Roy, Sunando; Teel, Elizabeth N.; Weinberg, Geoffrey A.; Payne, Daniel C.; Parashar, Umesh D.; Bowen, Michael D.;

Published:

Nov 20 2015

Source:

J Gen Virol. 97(2):389-402.

Description:

During the 2008-2009 rotavirus season of the Centers for Disease Control and Prevention New Vaccine Surveillance Network, one case of paediatric acute gastroenteritis associated with a rotavirus G14P[24] strain was identified. This was the first dete...

File Type:

[PDF - 995.51 KB]