Clinical Course and Long-Term Outcome of Hantavirus-Associated Nephropathia Epidemica, Germany

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Latus, Joerg ; Schwab, Matthias ; Tacconelli, Evelina ; Pieper, Friedrich-Michael ; Wegener, Daniel ; Dippon, Juergen ; Müller, Simon ; Zakim, David ; Segerer, Stephan ; Kitterer, Daniel ; Priwitzer, Martin ; Mezger, Barbara ; Walter-Frank, Birgit ; Corea, Angela ; Wiedenmann, Albrecht ; Brockmann, Stefan ; Pöhlmann, Christoph ; Alscher, M. Dominik ; Braun, Niko
• Description:
  Human infection with Puumala virus (PUUV), the most common hantavirus in Central Europe, causes nephropathia epidemica (NE), a disease characterized by acute kidney injury and thrombocytopenia. To determine the clinical phenotype of hantavirus-infected patients and their long-term outcome and humoral immunity to PUUV, we conducted a cross-sectional prospective survey of 456 patients in Germany with clinically and serologically confirmed hantavirus-associated NE during 2001-2012. Prominent clinical findings during acute NE were fever and back/limb pain, and 88% of the patients had acute kidney injury. At follow-up (7-35 mo), all patients had detectable hantavirus-specific IgG; 8.5% had persistent IgM; 25% had hematuria; 23% had hypertension (new diagnosis for 67%); and 7% had proteinuria. NE-associated hypertension and proteinuria do not appear to have long-term consequences, but NE-associated hematuria may. All patients in this study had hantavirus-specific IgG up to years after the infection.
• Subjects:
  Adult Cross-Sectional Studies Female Hematuria Hemorrhagic Fever With Renal Syndrome Humans Hypertension Male Middle Aged Prospective Studies
• Source:
  Emerg Infect Dis. 21(1):76-83.
• Document Type:
  Journal Article
• Place as Subject:
  Germany
• Volume:
  21
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3e76bdc05bca41c716a4decf1ef64fdb5323670b8a4fa2aef259364f4348a128
• Download URL:
  https://stacks.cdc.gov/view/cdc/26683/cdc_26683_DS1.pdf
• File Type:
  [PDF - 762.71 KB ]