Welcome to CDC stacks | Human Papillomavirus Prevalence in Invasive Laryngeal Cancer in the United States - 26526 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Human Papillomavirus Prevalence in Invasive Laryngeal Cancer in the United States
Filetype[PDF-313.37 KB]


Details:
  • Corporate Authors:
    The HPV Typing of Cancer Workgroup
  • Pubmed ID:
    25546150
  • Pubmed Central ID:
    PMC4278830
  • Description:
    Purpose

    Human papillomavirus (HPV) is a major risk factor for specific cancers of the head and neck, particularly malignancies of the tonsil and base of the tongue. However, the role of HPV in the development of laryngeal cancer has not been definitively established. We conducted a population-based, cancer registry study to evaluate and characterize the genotype-specific prevalence of HPV in invasive laryngeal cancer cases diagnosed in the U.S.

    Methods

    The presence of genotype-specific HPV DNA was evaluated using the Linear Array HPV Genotyping Test and the INNO-LiPA HPV Genotyping Assay in formalin-fixed paraffin embedded tissue from 148 invasive laryngeal cancer cases diagnosed in 1993–2004 within the catchment area of three U.S. SEER cancer registries.

    Results

    HPV DNA was detected in 31 of 148 (21%) invasive laryngeal cancers. Thirteen different genotypes were detected. Overall, HPV 16 and HPV 33 were the most commonly detected types. HPV was detected in 33% (9/27) of women compared with 18% (22/121) of men (p = 0.08). After adjustment for age and year of diagnosis, female patients were more likely to have HPV-positive laryngeal tumors compared to males (adjusted OR 2.84, 95% CI 1.07–7.51). Viral genotype differences were also observed between the sexes. While HPV 16 and 18 constituted half of HPV-positive cases occurring in men, among women, only 1 was HPV 16 positive and none were positive for HPV 18. Overall 5-year survival did not vary by HPV status.

    Conclusions

    HPV may be involved in the development of a subset of laryngeal cancers and its role may be more predominant in women compared to men.

  • Document Type:
  • Collection(s):
  • Funding:
    1U58DP000807-3/DP/NCCDPHP CDC HHS/United States
    N01 PC035137/PC/NCI NIH HHS/United States
    N01-PC-2010-00035/PC/NCI NIH HHS/United States
    N01-PC-35137/PC/NCI NIH HHS/United States
    N01-PC-35139/PC/NCI NIH HHS/United States
    N01-PC-35143/PC/NCI NIH HHS/United States
    P30 CA071789/CA/NCI NIH HHS/United States
No Related Documents.
You May Also Like: