Two-Year Longitudinal Outcomes of Subjective Cognitive Decline in Hispanics Compared to Non-hispanic Whites.

Details

• Alternative Title:
  Journal of Geriatric Psychiatry and Neurology, 2025, v. 38, no. 1: Two-Year Longitudinal Outcomes of Subjective Cognitive Decline in Hispanics Compared to Non-hispanic Whites.
• Journal Article:
  Journal of Geriatric Psychiatry and Neurology
• Personal Author:
  Boza-Calvo, Carolina ; Faustin, Arline ; Zhang, Yian ; Briggs, Anthony Q. ; Bernard, Mark A. ; Bubu, Omonigho M. ; Rao, Julia A. ; Gurin, Lindsey ; Ouedraogo Tall, Sakina ; Osorio, Ricardo S. ; Marsh, Karyn ; Shao, Yongzhao ; Masurkar, Arjun V.
• Description:
  Subjective cognitive decline (SCD), considered a preclinical dementia stage, is less understood in Hispanics, a high-risk group for dementia. We investigated SCD to mild cognitive impairment (MCI) progression risk, as well as baseline and longitudinal features of depressive symptoms, SCD complaints, and objective cognitive performance among Hispanics compared to non-Hispanic Whites (NHW).
  
  Hispanic (n = 23) and NHW (n = 165) SCD participants were evaluated at baseline and 2-year follow-up. Evaluations assessed function, depressive symptoms, SCD, and objective cognitive performance.
  
  Hispanics were at increased risk of progression to MCI (OR: 6.10, 95% CI 1.09-34.20,
  
  = .040). Hispanic participants endorsed more depressive symptoms at baseline (
  
  = .048) that worsened more longitudinally (OR: 3.16, 95% CI 1.18-8.51,
  
  = .023). Hispanic participants had increased SCD complaints on the Brief Cognitive Rating Scale (BCRS) (β = .40 SE: .17,
  
  = .023), and in specific BCRS domains: concentration (β = .13, SE: .07,
  
  = .047), past memory (β = .13, SE: .06,
  
  = .039) and functional abilities (β = .10, SE: .05,
  
  = .037). In objective cognitive performance, Hispanic ethnicity associated with decline in MMSE (β = -.27, SE: .13,
  
  = .039), MoCA (β = -.80 SE: .34,
  
  = .032), Trails A (β = 2.75, SE: .89,
  
  = .002), Trails B (β = 9.18, SE: 2.71,
  
  = .001) and Guild Paragraph Recall Delayed (β = -.80 SE: .28,
  
  = .005).
  
  Hispanic ethnicity associated with a significantly increased risk of 2-year progression of SCD to MCI compared to NHW. This increased risk associated with increased depressive symptoms, distinctive SCD features, and elevated amnestic and non-amnestic objective cognitive decline. This supports further research to refine the assessment of preclinical dementia in this high-risk group.
• Content Notes:
  Author manuscript
• Subjects:
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Cognitive Dysfunction
  • Depression
  • Disease Progression
  • Hispanic or Latino
  More +
• Keywords:
  • subjective cognitive decline
  • longitudinal studies
  • hispanic ethnicity
  • cognition
  • mild cognitive impairment
  • Alzheimer's disease
• Source:
  Journal of Geriatric Psychiatry and Neurology, 2025, v. 38, no. 1
• DOI:
  https://doi.org/10.1177/08919887241263097
• ISSN:
  0891-9887 ; 1552-5708
• Pubmed ID:
  39043156
• Pubmed Central ID:
  PMC12856748
• Document Type:
  Text
• Funding:
  P30 AG066512/AG/NIA NIH HHSUnited States/ ; U01 OH012486/OH/NIOSH CDC HHSUnited States/ ; R01 AG082278/AG/NIA NIH HHSUnited States/ ; P30 AG008051/AG/NIA NIH HHSUnited States/ ; RF1 AG083975/AG/NIA NIH HHSUnited States/ ; K23 AG068534/AG/NIA NIH HHSUnited States/ ; L30 AG064670/AG/NIA NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  23-31 (17 pdf pages)
• Volume:
  38
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/262076/cdc_262076_DS1.pdf
• File Type:
  [PDF - 375.68 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:af16792626a68e4efc9cc35bf2431ad0097508260c04ea101837fec8940e98688704ed7b05c9e777f778087f03a4faef68210c9e4cee34df918f7b3d36430f12