Relationships between Cognitive Complaints and Quality of Life in Older Adults with Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Normal Cognition

Details

• Alternative Title:
  Alzheimer Dis Assoc Disord
• Personal Author:
  Stites, Shana D. ; Harkins, Kristin ; Rubright, Jonathan D. ; Karlawish, Jason
• Description:
  Purpose ; To examine in persons with varying degrees of cognitive impairment the relationship between self-reports of cognitive complaints and quality of life (QOL). ; Method ; Older adults (n=259) with normal cognition, Mild Cognitive Impairment (MCI), and mild stage Alzheimer's disease (AD) dementia completed tests of cognition and self-report questionnaires about QOL and three kinds of cognitive complaints: cognitive difficulties, distress from cognitive difficulties, and believing you had more memory problems than most people. Bivariate, multivariable, and multivariate regression analyses assessed relationships between domains of QOL and each cognitive complaint. ; Results ; Bivariate and multivariable analyses controlling for severity of cognitive and functional impairment found that cognitive complaints were related to relatively lower quality of daily life (QOL-AD, DEM-QOL), greater depression (GDS), more anxiety (BAI), higher perceived stress (PSS), and lower general mental wellbeing (SF-12 MCS). ; Discussion ; Cognitive complaints have robust associations with QOL. These findings have implications for AD prevention trials and management of clinical populations.
• Subjects:
  • Aged
  • Alzheimer Disease
  • Cognition
  • Cognitive Dysfunction
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Quality of Life
  • Self Report
  More +
• Keywords:
  • self-rated health
  • Alzheimer's disease
  • self-reported symptoms
  • mild cognitive impairment
  • quality of life
• Source:
  Alzheimer Dis Assoc Disord. 32(4):276-283
• Pubmed ID:
  29944474
• Pubmed Central ID:
  PMC6249095
• Document Type:
  Text
• Funding:
  P30 AG010124/AG/NIA NIH HHSUnited States/ ; U48DP005053/ACL/ACL HHSUnited States/
• Genre:
  Journal Article
• Volume:
  32
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/158022/cdc_158022_DS1.pdf
• File Type:
  [PDF - 430.94 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:fab39436a2625bb36dcce82a6bb28acd24e0a374278db78b4a695b3912f025c340876af83539e7cceea4a2fabfc71a11b85bf06a8419a94bdec419e6900c8d00