Neuromodulation in Small Animal FMRI.

Details

• Alternative Title:
  Journal of Magnetic Resonance Imaging: JMRI, 2025, v. 61, no. 4: Neuromodulation in Small Animal FMRI.
• Journal Article:
  Journal of Magnetic Resonance Imaging: JMRI
• Personal Author:
  Hsu, Li-Ming ; Shih, Yen-Yu Ian
• Description:
  The integration of functional magnetic resonance imaging (fMRI) with advanced neuroscience technologies in experimental small animal models offers a unique path to interrogate the causal relationships between regional brain activity and brain-wide network measures-a goal challenging to accomplish in human subjects. This review traces the historical development of the neuromodulation techniques commonly used in rodents, such as electrical deep brain stimulation, optogenetics, and chemogenetics, and focuses on their application with fMRI. We discuss their advantageousness roles in uncovering the signaling architecture within the brain and the methodological considerations necessary when conducting these experiments. By presenting several rodent-based case studies, we aim to demonstrate the potential of the multimodal neuromodulation approach in shedding light on neurovascular coupling, the neural basis of brain network functions, and their connections to behaviors. Key findings highlight the cell-type and circuit-specific modulation of brain-wide activity patterns and their behavioral correlates. We also discuss several future directions and feature the use of mediation and moderation analytical models beyond the intuitive evoked response mapping, to better leverage the rich information available in fMRI data with neuromodulation. Using fMRI alongside neuromodulation techniques provide insights into the mesoscopic (relating to the intermediate scale between single neurons and large-scale brain networks) and macroscopic fMRI measures that correlate with specific neuronal events. This integration bridges the gap between different scales of neuroscience research, facilitating the exploration and testing of novel therapeutic strategies aimed at altering network-mediated behaviors. In conclusion, the combination of fMRI with neuromodulation techniques provides crucial insights into mesoscopic and macroscopic brain dynamics, advancing our understanding of brain function in health and disease. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 1.
• Content Notes:
  Author manuscript
• Subjects:
  • Magnetic Resonance Imaging
  • Animals
  • Brain
  • Optogenetics
  • Brain Mapping
  • Deep Brain Stimulation
  • Humans
  • Neurovascular Coupling
  • Rats
• Keywords:
  • fMRI
  • optogenetics
  • chemogenetics
  • deep brain stimulation
• Source:
  Journal of Magnetic Resonance Imaging: JMRI, 2025, v. 61, no. 4
• DOI:
  https://doi.org/10.1002/jmri.29575
• ISSN:
  1053-1807 ; 1522-2586
• Pubmed ID:
  39279265
• Pubmed Central ID:
  PMC11903207
• Document Type:
  Text
• Funding:
  S10 OD026796/CD/ODCDC CDC HHSUnited States/ ; P50HD103573/National Institute of Child Health and Human Development/ ; R21 NS133913/NS/NINDS NIH HHSUnited States/ ; R01 EB033790/EB/NIBIB NIH HHSUnited States/ ; R21 DA057503/DA/NIDA NIH HHSUnited States/ ; P60AA011605/AA/NIAAA NIH HHSUnited States/ ; RF1 MH117053/MH/NIMH NIH HHSUnited States/ ; R01 NS128278/NS/NINDS NIH HHSUnited States/ ; S10 MH124745/MH/NIMH NIH HHSUnited States/ ; U01 AA020023/AA/NIAAA NIH HHSUnited States/ ; R01 MH111429/MH/NIMH NIH HHSUnited States/ ; R21AG083589/AG/NIA NIH HHSUnited States/ ; S10 OD026796/OD/NIH HHSUnited States/ ; U01AA020023/AA/NIAAA NIH HHSUnited States/ ; P60 AA011605/AA/NIAAA NIH HHSUnited States/ ; R01 NS091236/NS/NINDS NIH HHSUnited States/ ; R41 MH113252/MH/NIMH NIH HHSUnited States/ ; R01 MH126518/MH/NIMH NIH HHSUnited States/ ; R21 AG083589/AG/NIA NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  1597-1617 (36 pdf pages)
• Volume:
  61
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/262018/cdc_262018_DS1.pdf
• File Type:
  [PDF - 3.23 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:81e163efc3b01ffec88a55a21817a621a97f6b3bd136fac7b225d840ecd887182b4ec1a5d740dd8ca9718ab8491359e4d2a3a2906978d420112092df2d2ffb57