New Mechanisms in Diisocyanate-mediated Allergy/toxicity: Are MicroRNAs in Play?

Details

• Alternative Title:
  Current Opinion in Allergy and Clinical Immunology, 2025, v. 25, no. 2: New Mechanisms in Diisocyanate-mediated Allergy/toxicity: Are MicroRNAs in Play?
• Journal Article:
  Current Opinion in Allergy and Clinical Immunology
• Personal Author:
  Lin, Chen-Chung ; Law, Brandon F. ; Hettick, Justin M.
• Description:
  To describe recent findings of diisocyanate-mediated mechanisms in allergy and toxicology by addressing the role of microRNA (miR) in immune responses that may contribute to the development of occupational asthma (OA).
  
  Studies of diisocyanate asthma have traditionally focused on the immune and inflammatory patterns associated with diisocyanate exposures; however, recognized knowledge gaps exist regarding the detailed molecular mechanism(s) of pathogenesis. Recent studies demonstrate the critical role endogenous microRNAs play as gene regulators in maintaining homeostasis of the human body, and in the pathophysiology of many diseases including asthma. Given that diisocyanate-OA shares many pathophysiological characteristics with asthma, it is likely that miR-mediated mechanisms are involved in the pathophysiology of diisocyanate-OA. Recent reports have shown that changes in expression of endogenous miRs are associated with exposure to the occupationally relevant diisocyanates, toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). Continued mechanistic study of these relevant miRs may lead to the development of novel biomarkers of occupational exposure and/or provide efficacious targets for therapeutic strategies in diisocyanate asthma.
  
  The molecular mechanisms underlying diisocyanate-OA pathophysiology are heterogeneous and complicated. In this review, we highlight recent research into the roles and potential regulation of miRs in diisocyanate-OA.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • MicroRNAs
  • Asthma, Occupational
  • Animals
  • Occupational Exposure
  • Isocyanates
  • Toluene 2,4-Diisocyanate
  • Hypersensitivity
• Keywords:
  • 4,4'-methylene diphenyl diisocyanate
  • diisocyanates
  • microRNA
  • occupational asthma
  • toluene diisocyanate
• Source:
  Current Opinion in Allergy and Clinical Immunology, 2025, v. 25, no. 2
• DOI:
  https://doi.org/10.1097/ACI.0000000000001043
• ISSN:
  1528-4050 ; 1473-6322
• Pubmed ID:
  39450940
• Pubmed Central ID:
  PMC11867871
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  75-82 (13 pdf pages)
• Volume:
  25
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261954/cdc_261954_DS1.pdf
• File Type:
  [PDF - 1.60 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:dfbfa087692d82ae0ab2d23ea0f5a7769c14a70c2865f5d6062a9b41d5bb6b03e6d36b12d7a65c7e5826314d2195e943e939eddb4d77596facfdefa91e55f5ad