Persistent Organic Pollutants and Endogenous Sex-related Hormones in Hispanic/Latino Adults: the Hispanic Community Health Study/study of Latinos (HCHS/SOL).

Details

• Alternative Title:
  Environmental Research, 2025, v. 267: Persistent Organic Pollutants and Endogenous Sex-related Hormones in Hispanic/Latino Adults: the Hispanic Community Health Study/study of Latinos (HCHS/SOL).
• Journal Article:
  Environmental Research
• Personal Author:
  Abasilim, Chibuzor ; Persky, Victoria ; Sargis, Robert M. ; Day, Tessa ; Tsintsifas, Konstantina ; Daviglus, Martha ; Cai, Jianwen ; Freels, Sally ; Grieco, Arielle ; Peters, Brandilyn A. ; Isasi, Carmen R. ; Talavera, Gregory A. ; Thyagarajan, Bharat ; Davis, Mark ; Jones, Richard ; Sjodin, Andreas ; Turyk, Mary E.
• Description:
  Previous studies have demonstrated associations of persistent organic pollutants (POPs) with sex-related hormones; however, findings were inconsistent. Sex-specific impacts and pathways through which adiposity influences associations are not completely understood. We sought to evaluate sex-specific associations of POPs serum concentration with sex-related hormones and to explore pathways through which adiposity may modify associations.
  
  We studied 1073 men and 716 postmenopausal women participating in the "Persistent Organic Pollutants, Endogenous Hormones, and Diabetes in Latinos" ancillary study which is a subcohort of the "Hispanic Community Health Study/Study of Latinos." We use baseline examination data collected from 2008 to 2011 to investigate associations between eight organochlorine pesticides (OCPs), five polychlorinated biphenyls (PCB) groups, sum of polybrominated diphenyl ethers and polybrominated biphenyl 153 on sex hormone binding globulin (SHBG) and various sex-related hormone levels. We examined associations cross-sectionally using linear and logistic regression models adjusted for complex survey design and confounders.
  
  PCBs and select OCPs were associated with increased SHBG in women and decreased estradiol (E2) and/or bioavailable E2 in men. For instance, per quartile increase in serum concentrations of ∑PCBs and oxychlordane were associated with decreased levels of E2 (β = -6.36 pmol/L; 95% CI: 10.7,-2.02 and β = -5.08 pmol/L; 95% CI: 8.11,-2.05) and bioavailable E2 (β = -4.48 pmol/L; 95% CI: 7.22,-1.73 and β = -4.23 pmol/L; 95% CI: 6.17,-2.28), respectively, in men, and increased levels of SHBG (β = 7.25 nmol/L; 95% CI:2.02,12.8 and β = 9.42 nmol/L; 95% CI:4.08,15.0), respectively, in women. p,p'-DDT and β-HCCH, and o,p'-DDT were also associated with decreased testosterone (T) and bioavailable T (ng/dL) levels in men. Adiposity modified associations in men, revealing stronger inverse associations of PCBs, PBDEs, and several OCPs with LH, SHBG, E2, bioavailable E2, T, and the ratios of LH to FSH and E2 to T in those with below median body mass index and waist-to-hip ratio.
  
  Distinct patterns of hormone dysregulation with increasing POPs serum concentration were identified in men and post-menopausal women. In men but less so in postmenopausal women, adiposity modified associations of POPs serum concentration with sex-related hormones.
• Content Notes:
  Author manuscript
• Subjects:
  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Environmental Pollutants
  • Estradiol
  • Gonadal Steroid Hormones
  • Halogenated Diphenyl Ethers
  More +
• Keywords:
  • Hispanics/latinos
  • Persistent organic pollutants
  • Sex hormones
  • Diabetes
  • Body mass index
  • Endocrine disruption
• Source:
  Environmental Research, 2025, v. 267
• DOI:
  https://doi.org/10.1016/j.envres.2024.120742
• ISSN:
  0013-9351 ; 1096-0953
• Pubmed ID:
  39743011
• Pubmed Central ID:
  PMC12591841
• Document Type:
  Text
• Funding:
  HHSN268201300005C/HL/NHLBI NIH HHSUnited States/ ; HHSN268201300001C/HL/NHLBI NIH HHSUnited States/ ; HHSN268201300003I/HL/NHLBI NIH HHSUnited States/ ; N01 HC065233/HL/NHLBI NIH HHSUnited States/ ; N01 HC065236/HL/NHLBI NIH HHSUnited States/ ; N01 HC065235/HL/NHLBI NIH HHSUnited States/ ; T42 OH008672/OH/NIOSH CDC HHSUnited States/ ; HHSN268201300004C/HL/NHLBI NIH HHSUnited States/ ; P30 DK111022/DK/NIDDK NIH HHSUnited States/ ; N01 HC065234/HL/NHLBI NIH HHSUnited States/ ; HHSN268201300003C/HG/NHGRI NIH HHSUnited States/ ; P30 ES027792/ES/NIEHS NIH HHSUnited States/ ; N01 HC065237/HL/NHLBI NIH HHSUnited States/ ; R01 ES025159/ES/NIEHS NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  120742 (31 pdf pages)
• Volume:
  267
• Download URL:
  https://stacks.cdc.gov/view/cdc/261817/cdc_261817_DS1.pdf
• File Type:
  [PDF - 749.80 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:1f70594c44c40488cbf4351250c4a22bf5889551b6589cf0031a1cc331dea46532a54730c3a294d734c85bb912f25ee20b9ae3928f81956c5fa7c1e6ea8dc50d