The Development of Frailty Trajectories in World Trade Center General Responders and the Association With World Trade Center Exposure.

Details

• Alternative Title:
  The Journal of Frailty & Aging, 2025, v. 14, no. 2: The Development of Frailty Trajectories in World Trade Center General Responders and the Association With World Trade Center Exposure.
• Journal Article:
  The Journal of Frailty & Aging
• Personal Author:
  Thompson, Hannah M. ; Ornstein, Katherine A. ; Colicino, Elena ; Pedretti, Nicolo Foppa ; Bello, Ghalib ; Sabra, Ahmad ; Thanik, Erin ; Lucchini, Roberto G. ; Crane, Michael ; Teitelbaum, Susan L. ; Hung, William W. ; Ko, Fred
• Description:
  As the World Trade Center (WTC) General Responder Cohort ages, it is imperative to study their aging process and identify factors that can be targeted for interventions.
  
  Our goal was to utilize a previously developed WTC Clinical Frailty Index (CFI) to identify distinct frailty trajectories and associated factors in this cohort.
  
  A latent class mixed model evaluated frailty trajectories using WTC CFIs. Multinomial regression models were used to assess associations between frailty trajectory and sociodemographic and WTC characteristics.
  
  We utilized data collected during routine WTC monitoring visits from 2004 until 2021.
  
  The participants were WTC general responders.
  
  Relative risk ratios (RRR) assessed associations with a 95 % confidence interval (CI).
  
  Three distinct linear frailty trajectories were identified: high CFI (indicating higher frailty), low CFI, and progressively increasing CFI. Compared with the low CFI group, females were more likely to be in the high CFI and progressively increasing CFI groups (RRR 1.66, 95 %CI 1.46, 1.90; RRR 1.32, 95 %CI 1.15, 1.53, respectively). Education beyond high school and elevated income were protective against high CFI and progressively increasing CFI groups. Individuals that self-identified as Hispanic had an elevated RRR for the high CFI group (RRR 1.17, 95 %CI 1.04, 1.31). Occupation on 9/11, such as construction and maintenance and repair, as well as high/very high WTC exposure were significantly associated with both the high CFI and progressively increasing CFI groups.
  
  Several sociodemographic and WTC variables were associated with more hazardous frailty trajectories in WTC general responders. This work is beneficial to informing and directing future interventions for those at higher-risk for more hazardous frailty progression.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • September 11 Terrorist Attacks
  • Frailty
  • Male
  • Emergency Responders
  • Middle Aged
  • Adult
  • Aged
  • Occupational Exposure
  More +
• Keywords:
  • Frailty trajectory
  • World trade center
  • WTC
• Source:
  The Journal of Frailty & Aging, 2025, v. 14, no. 2
• DOI:
  https://doi.org/10.1016/j.tjfa.2025.100027
• ISSN:
  2260-1341 ; 2273-4309
• Pubmed ID:
  40056412
• Pubmed Central ID:
  PMC12004615
• Document Type:
  Text
• Funding:
  K08 AG050808/AG/NIA NIH HHSUnited States/ ; U01 OH012473/OH/NIOSH CDC HHSUnited States/ ; R01 ES032242/ES/NIEHS NIH HHSUnited States/ ; R01 ES034521/ES/NIEHS NIH HHSUnited States/ ; P30 ES023515/ES/NIEHS NIH HHSUnited States/ ; T32 ES033955/ES/NIEHS NIH HHSUnited States/ ; U01 OH012068/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  New York City
• Pages in Document:
  100027 (16 pdf pages)
• Volume:
  14
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261616/cdc_261616_DS1.pdf
• File Type:
  [PDF - 449.27 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:869f20731988f1051974607d7d468f4c5dadd3afb78c1d0db9bc776f5b66223c9d17989b342c5d4ac67bd9544b7893bd7e0dbddb482f53eddfda54400a5838cf