Prevalence of Transfusion Transmitted Infections by Mode of Donation and Remuneration Status Among Blood Donors in Georgia, 2018-2023.

Details

• Alternative Title:
  Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis, 2025, v. 64, no. 3: Prevalence of Transfusion Transmitted Infections by Mode of Donation and Remuneration Status Among Blood Donors in Georgia, 2018-2023.
• Journal Article:
  Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis
• Personal Author:
  Shermadini, Ketevan ; Bloch, Evan M ; Shadaker, Shaun ; Alkhazashvili, Maia ; Chitadze, Nazibrola ; Surguladze, Sophia ; Tskhomelidze, Irinka ; Getia, Vladimer ; Adamia, Ekaterine ; Tohme, Rania A. ; Gabunia, Tamar
• Description:
  Global reform of blood transfusion services is underway in the country of Georgia. New legislation mandates exclusive collection of blood from non-remunerated blood donors in Georgia by July 2025. Retrospective data (2018-2023) from the National Blood Donor Registry were analyzed. The prevalence was calculated for human immunodeficiency virus (HIV) antigen/antibody (Ag/Ab), hepatitis C virus antibody (anti-HCV), hepatitis B surface antigen (HBsAg). Results were stratified by remuneration status and mode of donation. Descriptive analysis was performed to elucidate differences in positivity by year and donor type. During 2018-2023, there were a total of 548,530 donations from 221,492 blood donors in Georgia; 68.3 % of donors were male and the median age was 34 years (interquartile range: 2644). Overall, 17.0 % were paid, 24.9 % were replacement, 47.4 % were voluntary non-remunerated blood donors (VNRBD), and 10.7 % had ≥ 2 donations of varying remuneration type. Paid donors had an average of 2.5 donations per year, compared to 1.0 for replacement, and 1.1 for VNRBDs. During 2018-2023, the proportions of paid donors decreased (38.8-22.1 %); the proportions of replacement (19.1-26.0 %) and VNRBDs (38.7-48.3 %) increased. Among first-time donors, prevalence decreased during 2018-2023 for anti-HCV (2.0-0.9 %) but were stable for HBsAg (range: 1.9 %-2.1 %) and anti-HIV (range: 0.1 %-0.2 %). Among repeat donors, prevalence of anti-HCV decreased (from 0.3 % to 0.2 %) while rates were stable for anti-HIV (0.04 %-0.1 %), and HBsAg (0.1 % in all years). The findings underscore the importance of donor retention in concert with efforts to attain exclusive VNRBD.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Male
  • Female
  • Blood Donors
  • Adult
  • Prevalence
  • Retrospective Studies
  • Georgia (Republic)
  • Blood Transfusion
  • Transfusion Reaction
  More +
• Keywords:
  • blood transfusion
  • blood donors
  • Hepatitis C
  • Epidemiology
  • Georgia (Country)
• Source:
  Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis, 2025, v. 64, no. 3
• DOI:
  https://doi.org/10.1016/j.transci.2025.104110
• ISSN:
  1473-0502
• Pubmed ID:
  40157049
• Pubmed Central ID:
  PMC12146081
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; K23 HL151826/HL/NHLBI NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  104110 (13 pdf pages)
• Volume:
  64
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/261555/cdc_261555_DS1.pdf
• File Type:
  [PDF - 415.99 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:764c3118bff79e8653a020f40fc13e90aedf780e6c4ea6fcc40dd18b170319e051f813a7c82f260c702e19db44c1d68f9c0b5d213a6d873a7c7be261fd78f362