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Advancing blood transfusion safety using molecular detection in the country of Georgia
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8 2023
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Source: Transfus Clin Biol. 30(3):307-313
[PDF-283.30 KB]
Details:
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Alternative Title:Transfus Clin Biol
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Personal Author:
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Description:Background:
In 2015, the country of Georgia initiated its hepatitis C virus (HCV) elimination program. Given a high background incidence of HCV infection, centralized nucleic acid testing (NAT) of blood donations was prioritized for implementation.
Study design and methods:
Multiplex NAT screening for HIV, HCV and hepatitis B virus (HBV) was launched in January 2020. An analysis was conducted of serological and NAT donor/donation data for the first year of screening (through December 2020).
Results:
A total of 54,116 donations representing 39,164 unique donors were evaluated. Overall, 671 donors (1.7%) tested positive for at least one infectious marker by serology or NAT, with the highest prevalence among donors aged 40–49 years (2.5%; n = 200), male (1.9%; n = 524), replacement (2.8%; n = 153) and first time (2.1%; n = 642) donors. Sixty donations were seronegative but NAT positive, and therefore would not have been found by traditional serology testing alone. These were more likely among female vs. male (adjusted odds ratio [aOR] 2.06; 95% confidence interval [95%CI]: 1.05–4.05), paid (aOR 10.15; 95%CI: 2.80–36.86) or voluntary (aOR 4.30; 95%CI: 1.27–14.56) vs replacement, and repeat vs. first time (aOR 13.98; 95%CI: 4.06–48.12) donors. On repeat serological testing (including HBV core antibody [HBcAb] testing), 6 HBV + donations, 5 HCV + donations and 1 HIV + donations were deemed NAT yield (detected through the implementation of NAT, and would have otherwise been missed by serology screening alone).
Conclusion:
This analysis offers a regional model for NAT implementation, demonstrating the feasibility and clinical utility in a nationwide blood program.
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Source:
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Pubmed ID:36907246
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Pubmed Central ID:PMC10958484
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