Trends in New Hepatitis C Virus Infections Among Repeat Blood Donors - Georgia, 2017-2023.

Details

• Alternative Title:
  Transfusion Clinique Et Biologique: Journal de la Societe Francaise de Transfusion Sanguine, 2025, v. 32, no. 1: Trends in New Hepatitis C Virus Infections Among Repeat Blood Donors - Georgia, 2017-2023.
• Journal Article:
  Transfusion Clinique Et Biologique: Journal de la Societe Francaise de Transfusion Sanguine
• Personal Author:
  Shadaker, Shaun ; Baliashvili, Davit ; Alkhazashvili, Maia ; Getia, Vladimer ; Schumacher, Irina Tskhomelidze ; Surguladze, Sophia ; Handanagic, Senad ; Tohme, Rania A ; Bloch, Evan M
• Description:
  Blood donor cohorts are an underappreciated resource for surveillance and public health programming for infectious diseases. The incidence of hepatitis C virus (HCV) infection was evaluated in repeat blood donors in Georgia.
  
  Using data from the national hepatitis C screening registry, we calculated overall hepatitis C incidence for 2017-2023 and annual incidence during 2017-2022 among adults who donated blood at least twice and had a nonreactive HCV antibody (anti-HCV) test result upon first screening and a subsequent anti-HCV test conducted in any location. Rates of anti-HCV seroconversion and current infection were calculated by year, sex, age group, and location of last HCV screening and expressed per 100,000 person-years (PY).
  
  Of 101,443 blood donors with ≥ 2 anti-HCV results,775 (0.8%) seroconverted to anti-HCV reactive, of whom 403 (52.0%) had current infection. Incidence of anti-HCV seroconversion decreased from 408 per 100,000 PY in 2017 to 218 per 100,000 PY in 2022 and incidence of infection decreased from 172 per 100,000 PY in 2017 to 118 per 100,000 PY in 2022. Males, persons aged 18-39 years, and people last tested for HCV in prisons had the highest incidence rates for anti-HCV seroconversion and HCV infection, while persons last screened in blood banks and during antenatal care had the lowest.
  
  Despite the observed decline, incidence of HCV infection among repeat blood donors remains high in specific subgroups. Hepatitis C prevention, screening and treatment interventions need to particularly focus on incarcerated populations and young adults in Georgia.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Blood Donors
  • Male
  • Adult
  • Female
  • Hepatitis C
  • Adolescent
  • Young Adult
  • Georgia (Republic)
  • Incidence
  More +
• Keywords:
  • Blood transfusion
  • Blood Donors
  • Hepatitis C
  • Epidemiology
  • Incidence
  • Georgia (Country)
• Source:
  Transfusion Clinique Et Biologique: Journal de la Societe Francaise de Transfusion Sanguine, 2025, v. 32, no. 1
• DOI:
  https://doi.org/10.1016/j.tracli.2024.11.004
• ISSN:
  1246-7820 ; 1953-8022
• Pubmed ID:
  39547544
• Pubmed Central ID:
  PMC11867862
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; K23 HL151826/HL/NHLBI NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  39-43 (12 pdf pages)
• Volume:
  32
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/261921/cdc_261921_DS1.pdf
• File Type:
  [PDF - 446.11 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:942477fb671ca457910e1589885de564df56a0eaceb58ef7c791f2ae42518407f61b5519a2545193552dd33d973611cdbdbef4aeee564827c4fac064d87a15cb