Two Distinct Durable Human Class-switched Memory B Cell Populations Are Induced by Vaccination and Infection.

Details

• Alternative Title:
  Cell Reports, 2025, v. 44, no. 4: Two Distinct Durable Human Class-switched Memory B Cell Populations Are Induced by Vaccination and Infection.
• Journal Article:
  Cell Reports
• Personal Author:
  Perugino, Cory A. ; Liu, Hang ; Feldman, Jared ; Marbourg, Jess ; Guy, Thomas V. ; Hui, Anson ; Ingram, Nicole ; Liebaert, Julian ; Chaudhary, Neha ; Tao, Weiyang ; Jacob-Dolan, Catherine ; Hauser, Blake M. ; Mian, Zayd ; Nathan, Anusha ; Zhao, Zezhou ; Kaseke, Clarety ; Tano-Menka, Rhoda ; Getz, Matthew A. ; Senjobe, Fernando ; Berrios, Cristhian ; Ofoman, Onosereme ; Manickas-Hill, Zachary ; Wesemann, Duane R. ; Lemieux, Jacob E. ; Goldberg, Marcia B. ; Nündel, Kerstin ; Moormann, Ann ; Marshak-Rothstein, Ann ; Larocque, Regina C. ; Ryan, Edward T. ; Iafrate, John A. ; Lingwood, Daniel ; Gaiha, Gaurav ; Charles, Richelle ; Balazs, Alejandro B. ; Pandit, Aridaman ; Naranbhai, Vivek ; Schmidt, Aaaron G. ; Pillai, Shiv
• Description:
  Memory lymphocytes are durable cells that persist in the absence of antigen, but few human B cell subsets have been characterized in terms of durability. The relative durability of eight non-overlapping human B cell sub-populations covering 100% of all human class-switched B cells was interrogated. Only two long-lived B cell populations persisted in the relative absence of antigen. In addition to canonical germinal center-derived switched-memory B cells with an IgD
  
  CD27
  
  CXCR5
  
  phenotype, a second, non-canonical, but distinct memory population of IgD
  
  CD27
  
  CXCR5
  
  DN1 B cells was also durable, exhibited a unique TP63-linked transcriptional and anti-apoptotic signature, had low levels of somatic hypermutation, but was more clonally expanded than canonical switched-memory B cells. DN1 B cells likely evolved to preserve immunological breadth and may represent the human counterparts of rodent extrafollicular memory B cells that, unlike canonical memory B cells, can enter germinal centers and facilitate B cell and antibody evolution.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Memory B Cells
  • Vaccination
  • Immunoglobulin Class Switching
  • Immunologic Memory
  • Germinal Center
  • B-Lymphocytes
  • Immunoglobulin D
  • B-Lymphocyte Subsets
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
  More +
• Keywords:
  • Human B cells
  • human class-switched memory B cells
  • humoral immune durability
  • germinal center derived memory B cells
  • extrafollicular memory B cells
  • TP63 in lymphocytes
  • Clonal diversity
  • lymphocyte durability
• Source:
  Cell Reports, 2025, v. 44, no. 4
• DOI:
  https://doi.org/10.1016/j.celrep.2025.115472
• ISSN:
  2211-1247
• Pubmed ID:
  40173042
• Pubmed Central ID:
  PMC12820432
• Document Type:
  Text
• Funding:
  R01 AI153098/AI/NIAID NIH HHSUnited States/ ; R01 AI155447/AI/NIAID NIH HHSUnited States/ ; U19 AI110495/AI/NIAID NIH HHSUnited States/ ; R01 AI146785/AI/NIAID NIH HHSUnited States/ ; U01 CK000490/CK/NCEZID CDC HHSUnited States/ ; T32 GM144273/GM/NIGMS NIH HHSUnited States/ ; U01 CK000633/CK/NCEZID CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  115472 (27 pdf pages)
• Volume:
  44
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/261531/cdc_261531_DS1.pdf
• File Type:
  [PDF - 1.44 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:22701fa8327b17b97d9e70638dc49cdf10241c3f15dab52a925070845390941ef3149360cad6bf02e1561a7575d12c047616dd615ac498841fbd6b10663da04d