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Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells
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Mar 12 2014
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Source: Curr Opin Immunol. 2014; 0:64-70.
[PDF-651.18 KB]
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Alternative Title:Curr Opin Immunol
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Description:B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
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Pubmed ID:24632082
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Pubmed Central ID:PMC4069329
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Volume:0
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