Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells

Yang, Zhiyong; Robinson, Marcus J; Allen, Christopher D C

doi:10.1016/j.coi.2014.02.001

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells

Published Date:

Mar 12 2014

Publisher's site:

http://dx.doi.org/10.1016/j.coi.2014.02.001 New Site Icon

Source:

Curr Opin Immunol. 2014; 0:64-70.

[PDF-651.18 KB]

Details:

Personal Authors:

Yang, Zhiyong ; Robinson, Marcus J ; Allen, Christopher D C ;

Keywords:

[+]

Pubmed ID:

24632082

Pubmed Central ID:

PMC4069329

Description:

B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 HL117752/HL/NHLBI NIH HHS/United States
DP2HL117752/DP/NCCDPHP CDC HHS/United States
R01 AI103146/AI/NIAID NIH HHS/United States
R01AI103146/AI/NIAID NIH HHS/United States

Supporting Files:

	nihms576090.nxml	application/octet-stream
	nihms576090f1.gif	image/gif
	nihms576090f1.jpg	image/jpeg
	nihms576090f2.gif	image/gif
	nihms576090f2.jpg	image/jpeg

No Related Documents.

You May Also Like:

A Role for Regulatory T Cells in a Murine Model of Epicutaneous Toluene Diisocyanate Sensitization

Personal Author:

Long, Carrie Mae; Marshall, Nikki B.; Lukomska, Ewa; Kashon, Michael L.; Meade, B. Jean; Shane, Hillary; Anderson, Stacey E.;

Published:

Apr 21 2016

Source:

Toxicol Sci. 152(1):85-98.

Description:

Toluene diisocyanate (TDI) is a leading cause of chemical-induced occupational asthma which impacts workers in a variety of industries worldwide. Recently, the robust regulatory potential of regulatory T cells (Tregs) has become apparent, including t...

File Type:

[PDF - 2.94 MB]
αβ T Cells and a Mixed Th1/Th17 Response are Important in Organic Dust-Induced Airway Disease

Personal Author:

Poole, Jill A.; Gleason, Angela M.; Bauer, Christopher; West, William W.; Alexis, Neil; Reynolds, Stephen J.; Romberger, Debra J.; Kielian, Tammy;

Published:

Jul 24 2012

Source:

Ann Allergy Asthma Immunol. 109(4):266-273.e2.

Description:

Organic dust exposure in agricultural environments induces an inflammatory response that attenuates over time, yet repetitive dust exposures result in chronic lung diseases. Animal models resembling this chronic lung inflammatory response have been d...

File Type:

[PDF - 933.22 KB]
Population Based Model of Human Embryonic Stem Cell (hESC) Differentiation during Endoderm Induction

Personal Author:

Task, Keith; Jaramillo, Maria; Banerjee, Ipsita;

Published:

Mar 12 2012

Source:

PLoS One. 2012; 7(3).

Description:

The mechanisms by which human embryonic stem cells (hESC) differentiate to endodermal lineage have not been extensively studied. Mathematical models can aid in the identification of mechanistic information. In this work we use a population-based mode...

File Type:

[PDF - 784.36 KB]
Vaccines for mucosal immunity to combat emerging infectious diseases.

Personal Author:

van Ginkel, F. W.; Nguyen, H. H.; McGhee, J. R.;

Published:

2000 Mar-Apr

Source:

Emerg Infect Dis. 6(2):123-132.

Description:

The mucosal immune system consists of molecules, cells, and organized lymphoid structures intended to provide immunity to pathogens that impinge upon mucosal surfaces. Mucosal infection by intracellular pathogens results in the induction of cell- med...

File Type:

[PDF - 222.61 KB]
Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice

Personal Author:

Warren, Kristi J.; Wyatt, Todd A.; Romberger, Debra J.; Ailts, Isaak; West, William W.; Nelson, Amy J.; Nordgren, Tara M.; Staab, Elizabeth; Heires, Art J.; Poole, Jill A.;

Published:

Feb 21 2017

Source:

Safety (Basel). 3(1).

Description:

Inhalation of organic dusts in agricultural environments causes airway inflammatory diseases. Despite advances in understanding the airway response to dust-induced inflammation, less is known about the transition from lung injury to repair and recove...

File Type:

[PDF - 791.51 KB]