Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells

Yang, Zhiyong; Robinson, Marcus J; Allen, Christopher D C

doi:10.1016/j.coi.2014.02.001

i

Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells

Supporting Files

Mar 12 2014
By Yang, Zhiyong ; Robinson, Marcus J ; Allen, Christopher D C

Details

Alternative Title:

Curr Opin Immunol
Personal Author:

Yang, Zhiyong ; Robinson, Marcus J ; Allen, Christopher D C
Description:

B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
Subjects:

Animals Article B-Lymphocytes Cell Differentiation Cell Lineage Germinal Center Humans Immunoglobulin Class Switching Immunoglobulin E
Source:

Curr Opin Immunol. 2014; 0:64-70.
Pubmed ID:

24632082
Pubmed Central ID:

PMC4069329
Document Type:

Journal Article
Funding:

DP2 HL117752/HL/NHLBI NIH HHS/United States ; DP2HL117752/DP/NCCDPHP CDC HHS/United States ; R01 AI103146/AI/NIAID NIH HHS/United States ; R01AI103146/AI/NIAID NIH HHS/United States
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:9c1b8fa7be6a1576fa8e3716fb23f6cd5b442c39b7b2102b1931359a78e5d490
Download URL:

https://stacks.cdc.gov/view/cdc/30013/cdc_30013_DS1.pdf
File Type:

[PDF - 651.18 KB ]

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