Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells

Yang, Zhiyong; Robinson, Marcus J; Allen, Christopher D C

doi:10.1016/j.coi.2014.02.001

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Regulatory Constraints in the Generation and Differentiation of IgE-Expressing B Cells

Published Date:

Mar 12 2014

Publisher's site:

http://dx.doi.org/10.1016/j.coi.2014.02.001 New Site Icon

Source:

Curr Opin Immunol. 2014; 0:64-70.

[PDF - 651.18 KB]

Details:

Personal Authors:

Yang, Zhiyong ; Robinson, Marcus J ; Allen, Christopher D C ;

Keywords:

[+]

Pubmed ID:

24632082

Pubmed Central ID:

PMC4069329

Description:

B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP2 HL117752/HL/NHLBI NIH HHS/United States
DP2HL117752/DP/NCCDPHP CDC HHS/United States
R01 AI103146/AI/NIAID NIH HHS/United States
R01AI103146/AI/NIAID NIH HHS/United States

Supporting Files:

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