Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.

Details

• Alternative Title:
  Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 4: Changes in the Prevalence of Non-AIDS Conditions Among Hospitalized Persons With HIV in the United States and Canada, 2008-2018.
• Journal Article:
  Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
• Personal Author:
  Davy-Mendez, Thibaut ; Napravnik, Sonia ; Hogan, Brenna C. ; Eron, Joseph J. ; Gebo, Kelly A. ; Althoff, Keri N. ; Moore, Richard D. ; Silverberg, Michael J. ; Horberg, Michael A. ; Gill, M. John ; Colasanti, Jonathan A. ; Nijhawan, Ank ; Karris, Maile Y. ; Klein, Marina B. ; Lang, Raynell ; Lesko, Catherine R. ; Yendewa, George A. ; Kirk, Gregory D. ; McGinnis, Kathleen A. ; Berry, Stephen A.
• Corporate Authors:
  for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA)
• Description:
  Hospitalization causes among persons with HIV (PWH) have shifted to non-AIDS conditions, but the complete disease profile of hospitalized PWH has not been well described. To inform hospitalization and readmission prevention efforts, we examined non-AIDS disease prevalence among PWH hospitalized in 4 US cohorts and 1 Canadian cohort.
  
  Among PWH with ≥1 hospitalization from 2008 to 2018, we used log-binomial regression with generalized estimating equations to estimate trends in the annual prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease (CKD) stage ≥3, and multimorbidity (≥2 and ≥3 conditions), defined using longitudinal diagnosis, medication, and laboratory data.
  
  We examined 6781 hospitalized PWH who were 75% cisgender men, 40% White, and 38% Black. From 2008 to 2018, the proportion of PWH in care who had ≥1 hospitalization decreased from 9.6% to 6.3%. Age- and cohort-adjusted prevalence increased for hyperlipidemia (relative change per year: 3.6% 95% CI: 2.5%-4.7%), diabetes mellitus (2.8% 1.3%-4.4%), CKD (3.3% 1.7%-4.9%), ≥2 conditions (1.3% 0.6%-2.0%), and ≥3 conditions (3.0% 1.7%-4.3%), decreased for HCV infection (-2.0% -3.0%, -0.9%), and remained stable for HBV infection (1.6% -1.1%, 4.3%) and hypertension (0.4% -0.2%, 1.1%).
  
  Hospitalized PWH had an increasing burden of several non-AIDS conditions and multimorbidity not accounted for by aging alone. Further work is needed to understand these conditions' role in hospitalization risk among PWH. Our findings reinforce that hospital discharge planning in PWH should include efforts to ensure chronic conditions are adequately managed.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Male
  • HIV Infections
  • Female
  • Hospitalization
  • Prevalence
  • Middle Aged
  • Adult
  • Hepatitis C
  • Diabetes Mellitus
  More +
• Keywords:
  • HIV
  • aging
  • comorbidity
  • hypertension
  • hyperlipidemia
• Source:
  Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 4
• DOI:
  https://doi.org/10.1093/cid/ciaf167
• ISSN:
  1058-4838 ; 1537-6591
• Pubmed ID:
  40178532
• Pubmed Central ID:
  PMC12452224
• Document Type:
  Text
• Funding:
  National Institute for Mental Health/ ; K23 EY013707/EY/NEI NIH HHSUnited States/ ; U01 AI038855/AI/NIAID NIH HHSUnited States/ ; UL1 RR024131/RR/NCRR NIH HHSUnited States/ ; U01 HL146192/HL/NHLBI NIH HHSUnited States/ ; Ontario Ministry of Health and Long Term Care/ ; U01 AI069432/AI/NIAID NIH HHSUnited States/ ; U01 HL146240/HL/NHLBI NIH HHSUnited States/ ; 90051652/HS/AHRQ HHSUnited States/ ; U01 HL146241/HL/NHLBI NIH HHSUnited States/ ; R01 AA016893/AA/NIAAA NIH HHSUnited States/ ; P30 AI027767/AI/NIAID NIH HHSUnited States/ ; U01 DA036297/DA/NIDA NIH HHSUnited States/ ; P30 AI050409/AI/NIAID NIH HHSUnited States/ ; U01 HL146333/HL/NHLBI NIH HHSUnited States/ ; F31 AI124794/AI/NIAID NIH HHSUnited States/ ; P30 MH062246/MH/NIMH NIH HHSUnited States/ ; U01 AI069434/AI/NIAID NIH HHSUnited States/ ; DC/NIDCD NIH HHSUnited States/ ; Z01 CP010176/ImNIH/Intramural NIH HHSUnited States/ ; Z01CP010176/NH/NIH HHSUnited States/ ; CDC-200-2006-18797/NH/NIH HHSUnited States/ ; DE/NIDCR NIH HHSUnited States/ ; CAPMC/ CIHRCanada/ ; NR/NINR NIH HHSUnited States/ ; U54 GM133807/GM/NIGMS NIH HHSUnited States/ ; HCP-97105/Grady Health System/ ; P30 AI094189/AI/NIAID NIH HHSUnited States/ ; U01 HL146245/HL/NHLBI NIH HHSUnited States/ ; National Institute of Allergy And Infectious Diseases/ ; G12 MD007583/MD/NIMHD NIH HHSUnited States/ ; K24 DA000432/DA/NIDA NIH HHSUnited States/ ; U01 HL146205/HL/NHLBI NIH HHSUnited States/ ; U01 DA036935/DA/NIDA NIH HHSUnited States/ ; U01 HL146208/HL/NHLBI NIH HHSUnited States/ ; CBR-86906, CBR-94036/Grady Health System/ ; K01HL169020/HL/NHLBI NIH HHSUnited States/ ; HRSA/HRSA HHSUnited States/ ; R24 AI067039/AI/NIAID NIH HHSUnited States/ ; U01 HL146242/HL/NHLBI NIH HHSUnited States/ ; U01 AI038858/AI/NIAID NIH HHSUnited States/ ; U10 EY008057/EY/NEI NIH HHSUnited States/ ; U01 AI068636/AI/NIAID NIH HHSUnited States/ ; U01 HL146201/HL/NHLBI NIH HHSUnited States/ ; NS/NINDS NIH HHSUnited States/ ; U01 HL146193/HL/NHLBI NIH HHSUnited States/ ; U10 EY008052/EY/NEI NIH HHSUnited States/ ; Eunice Kennedy Shriver National Institute of Child Health and Human Development/ ; U01 AA020790/AA/NIAAA NIH HHSUnited States/ ; HG/NHGRI NIH HHSUnited States/ ; UL1 TR002378/TR/NCATS NIH HHSUnited States/ ; P30 AI110527/AI/NIAID NIH HHSUnited States/ ; R34 DA045592/DA/NIDA NIH HHSUnited States/ ; P30 AI027763/AI/NIAID NIH HHSUnited States/ ; K01 AI093197/AI/NIAID NIH HHSUnited States/ ; U01 AI069918/AI/NIAID NIH HHSUnited States/ ; K24 AI118591/AI/NIAID NIH HHSUnited States/ ; U01 AA013566/AA/NIAAA NIH HHSUnited States/ ; Government of Alberta, Canada/ ; N02 CP055504/CP/NCI NIH HHSUnited States/ ; 90047713/CC/CDC HHSUnited States/ ; K24 AI065298/AI/NIAID NIH HHSUnited States/ ; P30 AI027757/AI/NIAID NIH HHSUnited States/ ; UL1 TR000083/TR/NCATS NIH HHSUnited States/ ; U01AI069918, F31AI124794, F31DA037788, G12MD007583, K01AI093197, K01AI131895, K23EY013707, K24AI065298, K24AI118591, K24DA000432, KL2TR000421, N01CP01004, N02CP055504, N02CP91027, P30AI027757, P30AI027763, P30AI027767, P30AI036219, P30AI050409, P30AI050410, P30AI094189, P30AI110527, P30MH62246, R01AA016893, R01DA011602, R01DA012568, R01AG053100, R24AI067039, R34DA045592, U01AA013566, U01AA020790, U01AI038855, U01AI038858, U01AI068634, U01AI068636, U01AI069432, U01AI069434, U01DA036297, U01DA036935, U10EY008057, U10EY008052, U10EY008067, U01HL146192, U01HL146193, U01HL146194, U01HL146201, U01HL146202, U01HL146203, U01HL146204, U01HL146205, U01HL146208, U01HL146240, U01HL146241, U01HL146242, U01HL146245, U01HL146333, U24AA020794, U54GM133807, UL1RR024131, UL1TR000004, UL1TR000083, UL1TR002378, Z01CP010214/NH/NIH HHSUnited States/ ; U01 HL146204/HL/NHLBI NIH HHSUnited States/ ; R01 DA012568/DA/NIDA NIH HHSUnited States/ ; U01 HL146202/HL/NHLBI NIH HHSUnited States/ ; KL2 TR000421/TR/NCATS NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; K01 AI131895/AI/NIAID NIH HHSUnited States/ ; TGF-96118/Grady Health System/ ; DK/NIDDK NIH HHSUnited States/ ; F31 DA037788/DA/NIDA NIH HHSUnited States/ ; CDC-200-2015-63931/NH/NIH HHSUnited States/ ; R01 AG053100/AG/NIA NIH HHSUnited States/ ; U10 EY008067/EY/NEI NIH HHSUnited States/ ; K01 HL169020/HL/NHLBI NIH HHSUnited States/ ; P30 AI036219/AI/NIAID NIH HHSUnited States/ ; U01 HL146194/HL/NHLBI NIH HHSUnited States/ ; U24 AA020794/AA/NIAAA NIH HHSUnited States/ ; U01 HL146203/HL/NHLBI NIH HHSUnited States/ ; U01 AI068634/AI/NIAID NIH HHSUnited States/ ; P30 AI050410/AI/NIAID NIH HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Canada ; United States
• Pages in Document:
  806-814 (18 pdf pages)
• Volume:
  81
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/261521/cdc_261521_DS1.pdf
• File Type:
  [PDF - 562.29 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:1b5ce5c99864d47cc97a256b8d37853e37b615d919593b81489d363dbe2c095febcdca0776c9d5256778e0f4fa9ffc70bb94b0a5d1c84c270e052e5badb481ee