Demographic and Clinical Characteristics of Patients With Hepatitis C and Hepatitis B Co-Infection, Georgia, 2017-2023.

Details

• Alternative Title:
  Journal of Viral Hepatitis, 2025, v. 32, no. 10: Demographic and Clinical Characteristics of Patients With Hepatitis C and Hepatitis B Co-Infection, Georgia, 2017-2023.
• Journal Article:
  Journal of Viral Hepatitis
• Personal Author:
  Handanagic, Senad ; Shadaker, Shaun ; BaliashvilI, Davit ; Tskhomelidze Schumacher, Irina ; Armstrong, Paige A. ; Tohme, Rania A. ; Butsashvili, Maia
• Description:
  Persons co-infected with hepatitis C virus and hepatitis B virus (HCV-HBV) are at increased risk of developing liver disease compared with mono-infected individuals. In Georgia, all patients undergoing hepatitis C treatment are eligible for free testing for hepatitis B surface antigen (HBsAg). However, further hepatitis B evaluations and treatment are not free. We explored demographic and clinical characteristics associated with HCV-HBV co-infection among persons treated for HCV infection. Persons aged ≥ 18 years with HCV infection who initiated HCV treatment during 2017-2023 were included. Patients were grouped as HCV mono-infected, HCV-HBV co-infected (HBsAg positive), and HBV exposed (total HBV core antibody positive, HBsAg negative). We present descriptive analysis and adjusted prevalence ratios (aPR) with 95% confidence intervals (95% CI). Of 54,994 adults treated for hepatitis C, 68.1% had HCV mono-infection, 29.3% were previously exposed to HBV, and 2.6% had HCV-HBV co-infection. Persons who were aged 18-45 years (aPR: 1.75, 95% CI: 1.48-2.08), male (aPR: 1.38, 95% CI: 1.11-1.71), reported ever injecting drugs (aPR: 1.40, 95% CI: 1.19-1.66), had end-of-HCV treatment, alanine transaminase (ALT) levels > 80 IU/L (aPR: 2.14, 95% CI: 1.40-3.29) and did not achieve hepatitis C cure after treatment (aPR: 1.83, 95% CI: 1.13-2.95) were more likely to have HCV-HBV co-infection vs. HCV mono-infection. Patients who did not achieve cure and had persistently higher ALT levels after hepatitis C treatment were more likely to have HCV-HBV co-infection. Expanded access to hepatitis B care and treatment, and co-management of HBV infection along with HCV treatment in co-infected persons are needed to improve clinical outcomes.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Male
  • Female
  • Adult
  • Middle Aged
  • Coinfection
  • Young Adult
  • Adolescent
  • Hepatitis B
  • Hepatitis C
  More +
• Keywords:
  • co-infection
  • Georgia
  • hepatitis B
  • hepatitis C
• Source:
  Journal of Viral Hepatitis, 2025, v. 32, no. 10
• DOI:
  https://doi.org/10.1111/jvh.70067
• ISSN:
  1352-0504 ; 1365-2893
• Pubmed ID:
  40905619
• Pubmed Central ID:
  PMC12631122
• Document Type:
  Text
• Funding:
  CC/CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  e70067 (22 pdf pages)
• Volume:
  32
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/261114/cdc_261114_DS1.pdf
• File Type:
  [PDF - 554.33 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:131ddeb987ab6eb4e172f1c7c6598929f676752836d08cfd81c2b61c3598fb609f3a52a0539cc527d36af18846aeff1d00ab6d4deed78e9ce320d374d8cb4fd3