Association Between High-Risk Human Papillomavirus Prevalence and Circumcision Status Among Sexually Experienced Adult Men, 2013 to 2016, United States.

Details

• Alternative Title:
  Sexually Transmitted Diseases, 2025, v. 52, no. 11: Association Between High-Risk Human Papillomavirus Prevalence and Circumcision Status Among Sexually Experienced Adult Men, 2013 to 2016, United States.
• Journal Article:
  Sexually Transmitted Diseases
• Personal Author:
  Lewis, Rayleen M. ; Brewer, Sarah K. ; Gargano, Julia W. ; Querec, Troy D. ; Unger, Elizabeth R. ; Markowitz, Lauri E.
• Description:
  Randomized control trials in sub-Saharan countries found that male circumcision may prevent high-risk human papillomavirus (HR-HPV) acquisition. Using 2013-2016 National Health and Nutrition Examination Survey data, we explored the association between circumcision and HR-HPV among sexually experienced 18- to 59-year-old men.
  
  Self-collected penile specimens were tested for HPV DNA. We estimated weighted HR-HPV prevalence (positivity to ≥1 HR type: HPV-16/18/31/33/35/39/45/51/52/56/58/59/66/68) by circumcision status. The association between circumcision and HR-HPV was assessed using multivariable logistic regression models. Effect modification by circumcision on the association between number of lifetime sex partners and HR-HPV was explored.
  
  Overall, 77.7% of men reported being circumcised, with large variation by race/ethnicity and country of birth. High-risk HPV prevalence was significantly higher among circumcised (25.7%) than uncircumcised (20.4%) men; this was attenuated after adjustment for lifetime and new past-year sex partners (adjusted prevalence ratio, 1.10; 95% confidence interval, 0.92-1.32). There was evidence that circumcision modified the association between lifetime partners and HR-HPV, but HR-HPV prevalence increased with increasing number of partners in circumcised and uncircumcised men.
  
  Our observed lack of statistical association between circumcision and HR-HPV may differ from randomized trial results because of the differences between circumcised and uncircumcised men or differences in anatomic site sampled or timing of circumcision.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Male
  • Circumcision, Male
  • Papillomavirus Infections
  • Adult
  • Prevalence
  • Middle Aged
  • Adolescent
  • Young Adult
  • Sexual Partners
  More +
• Keywords:
  • Human papillomavirus
  • prevalence
  • male circumcision
  • National Health and Nutrition Examination Survey
• Source:
  Sexually Transmitted Diseases, 2025, v. 52, no. 11
• DOI:
  https://doi.org/10.1097/OLQ.0000000000002207
• ISSN:
  0148-5717 ; 1537-4521
• Pubmed ID:
  40549428
• Pubmed Central ID:
  PMC12302073
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  699-705 (16 pdf pages)
• Volume:
  52
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/261311/cdc_261311_DS1.pdf
• File Type:
  [PDF - 505.35 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ad07535d345384c200957162f0915bfa80fc4d0ed24434fd2bfb766deedd2fda6548b33118e2ed67b1d0bb55c6185fd977b4380e6f8ce393fc8205207b834f89