Oxidation-Degradable Resins for 3D-Printing of Cell-Responsive Biomaterials

Details

• Journal Article:
  Advanced Functional Materials
• Personal Author:
  Dos Santos, Reinaldo L. ; Wynn, Wesley ; Marquez, Lindsey ; Hoque, Ejajul ; Bruce, Karina A. ; Yavitt, Benjamin M. ; Harris, Greg M. ; Martin, John R.
• Description:
  Additive manufacturing, or 3D printing, has emerged as a powerful tool for rapidly generating tissue engineering constructs with complex architectures. While hydrolysis-sensitive polyesters are most commonly used to 3D print these scaffolds, once implanted, these materials often degrade prematurely before tissue regeneration is achieved. To address these limitations, this study introduces new oxidation-sensitive resins that can be 3D-printed into implants designed to selectively degrade when exposed to cell-produced reactive oxygen species (ROS). Although these ROS-triggerable polymers have shown promise for matching tissue growth with implant degradation, they have yet to be adapted into simple, low-cost formulations compatible with commercial 3D printers. Here, UV-photopolymerizable, ROS-sensitive resins are created from synthesized thioketal (TK) dithiols and commercial alkene crosslinkers. A novel small-scale screening method is developed to determine each resin's optimal concentrations of photo-initiator and inhibitor. All TK resins support fine-detail 3D printing, exhibit negligible in vitro cytotoxicity, and display tunable mechanical properties and oxidative sensitivity based on their respective chemistries. Finally, 3D-printed TK scaffolds implanted subcutaneously in rats undergo significant biodegradation over 4 weeks and foster more rapid tissue infiltration than 3D-printed polyester controls. These findings highlight the potential of oxidation-sensitive resins for creating cell-responsive, tissue-regenerating medical implants with complex architectures. Description provided by NIOSH
• Subjects:
  • Acrylic Resins
  • Occupational Health
  • Printing, Three-Dimensional
  • Safety
• Keywords:
  • Additive manufacturing
  • Three dimensional printing
  • 3D printing
  • Reactive oxygen species
  • ROS
  • Resins
  • Biological materials
  • Author Keywords: 3D printing
  • biomaterials
  • digital light processing
  More +
• ISSN:
  1616-301X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Chicago Region OSHA ; Ohio
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16 pdf pages
• Volume:
  36
• Issue:
  25
• NIOSHTIC Number:
  nn:20071721
• Citation:
  Adv Funct Mater 2026 Mar; 36(25):e22208
• Email:
  marti7j3@ucmail.uc.edu
• Federal Fiscal Year:
  2026
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  2005/07/01
• End Date:
  2026/06/30
• Download URL:
  https://stacks.cdc.gov/view/cdc/259947/cdc_259947_DS1.pdf
• File Type:
  [PDF - 2.83 MB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:621b90aec76010a8f2d8a0c71d18c2ddbca5dca75bc9c6625d53d2f948c70b68c21842528df36c5a00238183fd20892d3325617afe9c7052b52a11f84b71d486