Current Status of per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes Along Human Health Risk Assessment Steps

Details

• Journal Article:
  Current Allergy & Asthma Reports
• Personal Author:
  Dameris, Logan ; Carberry, Victoria ; Seifert, Cole ; Sherman, Joji ; Hu, Yufan ; Rebuli, Meghan E. ; Turpin, Barbara J. ; Surratt, Jason D. ; Smith, Gregory ; Rager, Julia E.
• Description:
  Purpose of Review: This review aims to summarize the effects of per- and poly-fluoroalkyl substances (PFAS) exposures on the lung, emphasizing data coverage across steps of human health risk assessments. Recent Findings: There is expansive literature characterizing PFAS contamination in water, but recent studies have identified PFAS as a component of air pollution, thus impacts on the lung have been an increasing point of inquiry. Mounting evidence from human clinical/epidemiological, animal, and in vitro investigations supports relationships between PFAS exposures and adverse pulmonary outcomes including asthma, allergies, infections, and cancer. Focusing on toxicology studies using animal and in vitro lung cell models, exposures to PFAS modulated inflammation/immune responses, oxidative stress, mucus production, surfactant properties, and epithelial barrier integrity, representing important mechanisms impacting pulmonary health. Summary: There are expanding datasets linking PFAS exposures to adverse pulmonary outcomes; however, these data originated from mostly oral/ingestion exposure and not from volatilized or aerosolized PFAS exposure designs. Furthermore, there is a general lack of data informing dose-response modeling and risk characterization, representing gaps needed to characterize pulmonary health risks.
• Subjects:
  Fluorocarbons Lung Occupational Health Respiratory System Risk Assessment Safety
• Keywords:
  Author Keywords: PFAS; Lung Toxicity; Pulmonary Health; Chemical Risk; Animal; In Vitro Per- And Polyfluoroalkyl Substances; PFAS; Lung Cells; Pulmonary Effects; Risk Assessment; Oxidative Stress; Immune Reaction; Air Pollution; Asthma; Allergies; Toxic Effects;
• Source:
  Curr Allergy Asthma Rep 2026 Apr; 26:30
• ISSN:
  1529-7322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; Atlanta Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  17 pdf pages
• Volume:
  26
• Issue:
  30
• NIOSHTIC Number:
  nn:20071519
• Contact Point Address:
  Gregory Smith, Curriculum in Toxicology and Environmental Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, US
• Email:
  gregory.j.smith@unc.edu
• Federal Fiscal Year:
  2026
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20050701
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ae039c611e5676042427b98d1459dfbc4787d64ec42b58167a8ab3ccad2db8810248992e854c50a1299023ec517363b887e067ddf4b09000bc1af4669911fe6d
• Download URL:
  https://stacks.cdc.gov/view/cdc/259116/cdc_259116_DS1.pdf
• File Type:
  [PDF - 1.45 MB ]