Permeation of 2-Butoxyethanol Through Multiple Layers of a Disposable Nitrile Glove Material and a Single Layer of Microflex 93-260

Details

• Journal Article:
  Materials
• Personal Author:
  Song Kuramoto, Eu Jin ; Que Hee, Shane S.
• Description:
  Double gloving of disposable gloves occurs in healthcare when extra protection is required against carcinogens, sensitizers, pathogens and sharps. Triple gloving is much rarer. The resistances of single, double and triple layers of disposable nitrile glove material against 2-butoxyethanol (2-BE) were compared with the resistance of a single layer of Microflex 93-260 (Microflex). Three 2.54 cm ASTM F739 permeation cells with closed-loop water collection without recirculation in a moving tray water bath at 35.0 +/- 0.5 degrees C facilitated the permeation relative to a blank cell. Capillary gas chromatography/mass spectrometry allowed the determination of the standardized breakthrough time (SBT), steady state permeation rate (SSPR) and cumulated permeated mass/area (CPM/A) by 30 min. Two nitrile layers (267 +/- 14 µm) were about the same thickness as the Microflex layer (249 +/- 6 µm). Statistical analysis showed equivalence at p ≤ 0.05 of the multiple layers and the Microflex layer relative to average SBT and CPM/A by 30 min, all such comparisons with the single nitrile layer also being statistically different. The triple layer had an average SSPR or post-breakthrough permeation rate 8 times lower than its single layer, while that for the Microflex layer was 1.5 times lower. Thus, the Microflex layer in terms of CPM/A by 30 min at 210 +/- 40 µg/cm2 appeared closer to two nitrile layers (520 +/- 560 µg/cm2) than three (93 +/- 93 µg/cm2).
• Subjects:
  Gloves Nitriles Occupational Health Safety
• Keywords:
  Author Keywords: 2-butoxyethanol; Disposable Nitrile Gloves; Double And Triple Gloving; Microflex 93-260; Permeation Materials Testing; Gloves; 2-Butoxyethanol; Nitriles; Skin Exposure;
• Source:
  Materials 2025 Nov; 18(21):5055
• ISSN:
  1996-1944
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; San Francisco Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11 pdf pages
• Volume:
  18
• NIOSHTIC Number:
  nn:20071249
• Contact Point Address:
  Shane Que Hee, Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, 650 Charles Young Jr. Drive South, Los Angeles, CA 90095-1772, USA
• Email:
  squehee@ucla.edu
• CAS Registry Number:
  2-Butoxyethanol (CAS RN 111-76-2)
• Federal Fiscal Year:
  2026
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:891e1cae8931b128e3da015a32b8b20442c9a15e3d19960331fc8fc20e5b5175f2eca9b73888d5f85e043f2d79f0bd993804c87dbf4c7715344406d64b0aae1c
• Download URL:
  https://stacks.cdc.gov/view/cdc/258727/cdc_258727_DS1.pdf
• File Type:
  [PDF - 648.24 KB ]