Novel Core-Shell Nanostructure of E-Poly-L-Lysine and Polyamide-6 Polymers for Reusable and Durable Antimicrobial Function

Details

• Journal Article:
  Polymers
• Personal Author:
  Purandare, Saloni ; Li, Rui ; Xiang, Chunhui ; Song, Guowen
• Description:
  Antimicrobial function in protective and medical textiles is an essential safety feature since textiles can become breeding grounds for microorganisms. Ideally, the antimicrobial function in textiles should be non-toxic, stable, and durable. This study explores a core-shell nanofiber with a core of the cationic biopolymer e-poly-L-lysine (PL) and shell of structurally similar and biocompatible polyamide-6 (PA). The core-shell structure is expected to have a more stable antimicrobial function than its monolithic counterpart. Further, thermal crosslinking is expected to prevent rapid diffusion of the water-soluble PL. Therefore, this study establishes a comparison between a monolithic (control), a core-shell (CS), and a thermally crosslinked core-shell (CL-CS) nanofiber of PL and PA. Morphological analysis confirmed the successful generation of the core-shell nanofibers. All the samples exhibited hydrophilic behavior and antimicrobial function. However, the control sample showcased significantly reduced zones of inhibition in antimicrobial testing with 21 days of bacterial exposure (1.027 +/- 0.072 cm2), as compared to 24 h bacterial exposure (1.347 +/- 0.151 cm2). On the other hand, the zones of inhibition for 24 h vs. 21 days for CS (1.265 +/- 0.042 cm2 vs. 1.052 +/- 0.235 cm2) and CL-CS (1.128 +/- 0.161 cm2 vs. 1.106 +/- 0.047 cm2) showed no significant differences. Therefore, the core-shell structure allowed for sustainable and durable antimicrobial action. Lastly, the CL-CS sample exhibited reusable antimicrobial function owing to the core-shell structure paired with thermal crosslinking. This study showcases a fiber system with non-toxic, durable, and reusable antimicrobial function. This study builds grounds for the development and multifaceted holistic characterization of safe, stable, and scalable antimicrobial textiles.
• Subjects:
  Nanofibers Occupational Health Polymers Protective Clothing Safety Textiles
• Keywords:
  Author Keywords: E-poly-L-lysine; Polyamide-6; Nanofiber; Coaxial Electrospinning; Core-shell Nanofiber; Antimicrobial; Non-toxic; Reusable Antimicrobial; Stable Antimicrobial Nanofibers; Protective Clothing; Polymers; Textiles; Antimicrobials; Nanostructures;
• Source:
  Polymers 2025 Dec; 17(23):3195
• ISSN:
  2073-4360
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; North Carolina ; Atlanta Region [OSHA] ; Kansas City Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16 pdf pages
• Volume:
  17
• NIOSHTIC Number:
  nn:20071202
• Contact Point Address:
  Chunhui Xiang, Department of Apparel, Events, and Hospitality Management, Iowa State University of Science and Technology, Ames, IA 50011, USA
• Email:
  chxiang@iastate.edu
• Federal Fiscal Year:
  2026
• Performing Organization:
  Iowa State University
• Peer Reviewed:
  True
• Start Date:
  20210930
• End Date:
  20250929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6bbc89e4eb3878d66ebbd43fc1062964eeb57dbf72719d52942b98c8732378a3ea415d2ca6316a1658b85b1e88abd2a3c1ee0f9beded67344c89488619b92a27
• Download URL:
  https://stacks.cdc.gov/view/cdc/258681/cdc_258681_DS1.pdf
• File Type:
  [PDF - 2.05 MB ]