Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Vlasova, Anastasia N. ; Marthaler, Douglas ; Wang, Qiuhong ; Culhane, Marie R. ; Rossow, Kurt D. ; ... More +
Vlasova, Anastasia N. ; Marthaler, Douglas ; Wang, Qiuhong ; Culhane, Marie R. ; Rossow, Kurt D. ; Rovira, Albert ; Collins, James ; Saif, Linda J. Less -
Description:
Porcine epidemic diarrhea virus (PEDV), which emerged in the United States in 2013, has spread throughout North America. Limited availability of PEDV complete genomes worldwide has impeded our understanding of PEDV introduction into the United States. To determine the relationship between the North American strains and global emerging and historic PEDV strains, we sequenced and analyzed complete genomes of 74 strains from North America; the strains clustered into 2 distinct clades. Compared with the initially reported virulent US PEDV strains, 7 (9.7%) strains from 4 states contained insertions and deletions in the spike gene (S INDELs). These S INDEL strains share 99.8%-100% nt identity with each other and 96.2%-96.7% nt identity with the initial US strains. Furthermore, the S INDEL strains form a distinct cluster within North American clade II, sharing 98.6%-100% nt identity overall. In the United States, the S INDEL and original PEDV strains are co-circulating and could have been introduced simultaneously.
Subjects:
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Complete Genome Analysis Open Reading Frame 1 ORF 1 PEDV Variant Phylogenetic Analysis Pigs Porcine Epidemic Diarrhea Virus Recombination Identification Analysis Research S INDEL Strains Single Nucleotide Polymorphisms Spike Gene US Strains Virulent Strains Viruses
Source:
Emerg Infect Dis. 20(10):1620-1628.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:20098c868592871003672fe8927d2be2bb2d506ebe41b51e16411a010a5fff84
Download URL:
https://stacks.cdc.gov/view/cdc/25667/cdc_25667_DS1.pdf
File Type:

Supporting Files

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  	14-0491-Techapp-s1.pdf	pdf
  	14-0491_Final.nxml	txt

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