Effects of Mefloquine Use on Plasmodium vivax Multidrug Resistance

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Khim, Nimol ; Andrianaranjaka, Voahangy ; Popovici, Jean ; Kim, Saorin ; Ratsimbasoa, Arsene ; Benedet, Christophe ; Barnadas, Celine ; Durand, Remy ; Thellier, Marc ; Legrand, Eric ; Musset, Lise ; Menegon, Michela ; Severini, Carlo ; Nour, Bakri Y.M. ; Tichit, Magali ; Bouchier, Christiane ; Mercereau-Puijalon, Odile ; Ménard, Didier
• Description:
  Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infection triggered by P. falciparum infections expose non-P. falciparum parasites to mefloquine. To assess the consequences of such unintentional treatments on P. vivax, we studied variations in number of Pvmdr-1 (PlasmoDB accession no. PVX_080100, NCBI reference sequence NC_009915.1) copies worldwide in 607 samples collected in areas with different histories of mefloquine use from residents and from travelers returning to France. Number of Pvmdr-1 copies correlated with drug use history. Treatment against P. falciparum exerts substantial collateral pressure against sympatric P. vivax, jeopardizing future use of mefloquine against P. vivax. A drug policy is needed that takes into consideration all co-endemic species of malaria parasites.
• Subjects:
  Drug Resistance Gene Expression Regulation Humans Malaria, Falciparum Malaria, Vivax Mefloquine Multidrug Resistance-Associated Proteins Plasmodium Falciparum Plasmodium Vivax Protozoan Proteins
• Source:
  Emerg Infect Dis. 20(10):1637-1644.
• Document Type:
  Journal Article
• Place as Subject:
  Cambodia ; French Guiana ; Madagascar ; Sudan
• Volume:
  20
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:7c2b6e62109064781644db4a9eafe155fce7c7979fef7fa4cd92d6d7c6a10c87
• Download URL:
  https://stacks.cdc.gov/view/cdc/25663/cdc_25663_DS1.pdf
• File Type:
  [PDF - 546.21 KB ]