Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Shah, Naman K. ; Alker, Alisa P. ; Sem, Rithy ; Susanti, Agustina Ika ; Muth, Sinuon ; ... More +
Shah, Naman K. ; Alker, Alisa P. ; Sem, Rithy ; Susanti, Agustina Ika ; Muth, Sinuon ; Maguire, Jason D. ; Duong, Socheat ; Ariey, Frederic ; Meshnick, Steven R. ; Wongsrichanalai, Chansuda ; Less -
Description:
We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.
Subject:
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Adolescent
Adult
Animals
Antimalarials
Artemisinins
Artesunate
Dispatch
Drug Resistance, Multiple
Female
Gene Dosage
Genes, Protozoan
Humans
Malaria, Falciparum
Male
Mefloquine
Multidrug Resistance-Associated Proteins
Plasmodium Falciparum
Population Surveillance
Protozoan Proteins

Source:
Emerg Infect Dis. 14(10):1637-1640 ;
Pubmed ID:
18826834
Pubmed Central ID:
PMC2609877
Document Type:
Journal Article ;
Funding:
D43 TW007402/TW/FIC NIH HHS/United States ; PD 5D43TW007402-02/TW/FIC NIH HHS/United States ;
D43 TW007402/TW/FIC NIH HHS/United States ; PD 5D43TW007402-02/TW/FIC NIH HHS/United States ; Less -
Place as Subject:
Cambodia ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:649f7aa2e1645778b1c456437efe2248327955942329666ab760adda6b06319f
File Type:

Supporting Files

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