Molecular Surveillance for Multidrug-Resistant Plasmodium falciparum, Cambodia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Shah, Naman K. ; Alker, Alisa P. ; Sem, Rithy ; Susanti, Agustina Ika ; Muth, Sinuon ; Maguire, Jason D. ; Duong, Socheat ; Ariey, Frederic ; Meshnick, Steven R. ; Wongsrichanalai, Chansuda
• Description:
  We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.
• Subjects:
  Adolescent Adult Animals Antimalarials Artemisinins Artesunate Dispatch Drug Resistance, Multiple Female Gene Dosage Genes, Protozoan Humans Malaria, Falciparum Male Mefloquine Multidrug Resistance-Associated Proteins Plasmodium Falciparum Population Surveillance Protozoan Proteins

  More +
• Source:
  Emerg Infect Dis. 14(10):1637-1640
• Pubmed ID:
  18826834
• Pubmed Central ID:
  PMC2609877
• Document Type:
  Journal Article
• Funding:
  D43 TW007402/TW/FIC NIH HHS/United States ; PD 5D43TW007402-02/TW/FIC NIH HHS/United States
• Place as Subject:
  Cambodia
• Volume:
  14
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:649f7aa2e1645778b1c456437efe2248327955942329666ab760adda6b06319f
• Download URL:
  https://stacks.cdc.gov/view/cdc/17192/cdc_17192_DS1.pdf
• File Type:
  [PDF - 275.33 KB ]