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Confirmed Bacillus anthracis Infection among Persons Who Inject Drugs, Scotland, 2009–2010
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Sep 2014
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Source: Emerg Infect Dis. 20(9):1452-1463.
[PDF-736.15 KB]
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Alternative Title:Emerg Infect Dis
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Description:Patients who died had an increased sequential organ failure assessment score and need for vasopressors.|In Scotland, the 2009 outbreak of | infection among persons who inject drugs resulted in a 28% death rate. To compare nonsurvivors and survivors, we obtained data on 11 nonsurvivors and 16 survivors. Time from | exposure to symptoms or hospitalization and skin and limb findings at presentation did not differ between nonsurvivors and survivors. Proportionately more nonsurvivors had histories of excessive alcohol use (p = 0.05) and required vasopressors and/or mechanical ventilation (p|0.01 for each individually). Nonsurvivors also had higher sequential organ failure assessment scores (mean | SEM) (7.3 | 0.9 vs. 1.2 | 0.4, p<0.0001). Antibacterial drug administration, surgery, and anthrax polyclonal immune globulin treatments did not differ between nonsurvivors and survivors. Of the 14 patients who required vasopressors during hospitalization, 11 died. Sequential organ failure assessment score or vasopressor requirement during hospitalization might identify patients with injectional anthrax for whom limited adjunctive therapies might be beneficial.
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