Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster.

Details

• Personal Author:
  Doddi S ; Giricz O ; Goldfarb DG ; Hall CB ; Landgren O ; Luft BJ ; Mueller AK ; Murata, Kiyoshi ; Prezant DJ ; Ramanathan L ; Shah UA ; Thoren K ; Verma A ; Yang X ; Zeig-Owens R
• Description:
  An elevated risk of myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS), was identified among Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters. Further investigation was needed to determine if these findings were reproducible in a more heterogeneous WTC-exposed rescue/recovery workers cohort, the Stony Brook University-General Responder Cohort GRC (SBU-GRC). MGUS risk was compared between the cohorts and to published general population estimates from Olmsted County, Minnesota, USA. In this observational seroprevalence study, odds ratios (OR) and age-standardized risk ratios (RR) of MGUS (M-spike and light-chain-MGUS combined), M-spike, and light-chain-MGUS were estimated using logistic regression. Age-standardized prevalences were calculated for white males aged 50-79; RRs were estimated by comparing risk in the WTC-exposed cohort with the Olmsted County screened cohort. SBU-GRC had elevated odds of MGUS compared with FDNY (OR = 1.38; 95%CI = 1.00-1.89). The age-standardized prevalence of MGUS was 9.0/100 persons (95%CI = 7.5-10.6), over two-fold higher than the general population (RR = 2.08; 95%CI = 1.72-2.51); the age-standardized prevalence of light-chain-MGUS was 3.5-fold higher (RR = 3.54; 95%CI = 2.52-4.97). This study adds to mounting evidence supporting an association between WTC/environmental exposures and MGUS among rescue/recovery workers. Access to MGUS screenings for the entire WTC-exposed cohort could allow for treatment interventions that improve survival. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Emergency Responders Firefighters Hematologic Tests Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  World Trade Center; WTC; Fire fighters; Hematology; Myeloid tissue; Cohort studies; Emergency responders; Rescue workers; Cancer rates
• ISSN:
  2044-5385
• Document Type:
  Text
• Funding:
  Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Florida ; New York ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  12
• Issue:
  8
• NIOSHTIC Number:
  nn:20065887
• Citation:
  Blood Cancer J 2022 Aug; 12(8):120
• Contact Point Address:
  Ola Landgren, Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA
• Email:
  col15@miami.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York City Fire Department
• Peer Reviewed:
  True
• Start Date:
  20140701
• Source Full Name:
  Blood Cancer Journal
• End Date:
  20170630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:97cc5c143ddac2f86cf9d68da81a02c0cdb9ea475632664f4ce14c4d6eeb47453556a562b0fb0ea5930f779c93afe7a8b9f818b354ee6bbfc07be3de73551ff7
• Download URL:
  https://stacks.cdc.gov/view/cdc/249588/cdc_249588_DS1.pdf
• File Type:
  [PDF - 601.40 KB ]