Cancer in General Responders Participating in World Trade Center Health Programs, 2003–2013

Details

• Personal Author:
  Crane MA ; Dasaro CR ; Harrison DJ ; Lucchini RG ; Luft BJ ; Moline JM ; Sacks HS ; Shapiro MZ ; Teitelbaum SL ; Thanik ES ; Todd AC ; Udasin IG ; Wallenstein SR
• Description:
  Background: Following the September 11, 2001, attacks on the World Trade Center (WTC), thousands of workers were exposed to an array of toxins known to cause adverse health effects, including cancer. This study evaluates cancer incidence in the WTC Health Program General Responder Cohort occurring within 12 years post exposure. Methods: The study population consisted of 28 729 members of the General Responder Cohort enrolled from cohort inception, July 2002 to December 31, 2013. Standardized incidence ratios (SIRs) were calculated with cancer case inclusion and follow-up starting post September 11, 2001 (unrestricted) and, alternatively, to account for selection bias, with case inclusion and follow-up starting 6 months after enrollment in the WTC Health Program (restricted). Case ascertainment was based on linkage with six state cancer registries. Under the restricted criterion, hazard ratios were estimated using multivariable Cox proportional hazards models for all cancer sites combined and for prostate cancer. Results: Restricted analyses identified 1072 cancers in 999 responders, with elevations in cancer incidence for all cancer sites combined (SIR = 1.09, 95% confidence interval [CI] = 1.02 to 1.16), prostate cancer (SIR = 1.25, 95% CI = 1.11 to 1.40), thyroid cancer (SIR = 2.19, 95% CI = 1.71 to 2.75), and leukemia (SIR = 1.41, 95% CI = 1.01 to 1.92). Cancer incidence was not associated with any WTC exposure index (composite or individual) for all cancer sites combined or for prostate cancer. Conclusion: Our analyses show statistically significant elevations in cancer incidence for all cancer sites combined and for prostate and thyroid cancers and leukemia. Multivariable analyses show no association with magnitude or type of exposure. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Emergency Responders Epidemiology Health Care Facilities Workforce And Services Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: Cancer Cancer Rates Cohort Studies Emergency Responders Leukemia Medical Monitoring Prostate Prostate Cancer Rescue Workers September 11 Terrorist Attacks Thyroid Cancer Thyroid Gland Disorders World Trade Center WTC

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• ISSN:
  2515-5091
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  4
• Issue:
  1
• NIOSHTIC Number:
  nn:20068361
• Citation:
  JNCI Cancer Spectr 2020 Feb; 4(1):pkz090
• Contact Point Address:
  M. Z. Shapiro, MS, Department of Environmental Medicine and Public Health, Box 1057, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029
• Email:
  moshe.shapiro@mssm.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  State University of New York Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20040715
• Source Full Name:
  JNCI Cancer Spectrum
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f5738e448fadb67651a473a0a52d6d49efdcc33625427b72948af77468279cb96cc4141a44603a6816c606cdec9526241f717313427ddb281015aab00c127ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/230525/cdc_230525_DS1.pdf
• File Type:
  [PDF - 891.50 KB ]