Metalworking fluid exposure and stroke mortality among US autoworkers.

Details

• Personal Author:
  Arteaga D ; Chen KT ; Costello S ; Eisen EA ; Elser H ; Picciotto S ; Reimer R
• Description:
  Although air pollution is an important risk factor for stroke, few studies have considered the impact of workplace exposure to particulate matter (PM). We examined implications of exposure to PM composed of metalworking fluids (MWFs) for stroke mortality in the United Autoworkers-General Motors cohort. Cox proportional hazards models with age as the timescale were used to estimate the association of cumulative straight, soluble, and synthetic MWF exposure with stroke mortality, controlling for sex, race, plant, calendar year, and hire year. Among 38,553 autoworkers followed during 1941-1995, we identified 114 ischemic stroke deaths and 113 hemorrhagic stroke deaths. Overall stroke mortality risk was increased among workers in the middle exposure category for straight MWF (hazard ratio (HR) = 1.31, 95% confidence interval (CI): 0.87, 1.98) and workers in the highest exposure category for synthetic MWF (HR = 1.94, 95% CI: 1.13, 3.16) compared with workers who had no direct exposure. Ischemic stroke mortality risk was increased among workers in the highest exposure categories for straight MWF (HR = 1.45, 95% CI: 0.83, 2.52) and synthetic MWF (HR = 2.39, 95% CI: 1.39, 4.50). We observed no clear relationship between MWF exposure and hemorrhagic stroke mortality. Our results support a potentially important role for occupational PM exposures in stroke mortality and indicate the need for further studies of PM exposure and stroke in varied occupational settings. [Description provided by NIOSH]
• Subjects:
  Automobiles Epidemiology Mortality Occupational Health Particulate Matter Safety
• Keywords:
  Author Keywords: PM2.5; Hemorrhagic Stroke; Ischemic Stroke; Particulate Matter Metalworking Fluids; MWFs; Automotive Industry; Mortality Rates; Particulates; Epidemiology; Ischemic Stroke; Hemorrhagic Stroke;
• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  191
• Issue:
  6
• NIOSHTIC Number:
  nn:20065374
• Citation:
  Am J Epidemiol 2022 Jun; 191(6):1040-1049
• Contact Point Address:
  Dr. Holly Elser, Department of Neurology, 3 Gates, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104
• Email:
  holly.elser@pennmedicine.upenn.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3af345803f524aaa678d9a408271c31170c620eed5c33279699742b77290e48473a10b59b493fcf3fccfac8ea53821670fdffde84f8aa07d5db5c186ee7d4f8e
• Download URL:
  https://stacks.cdc.gov/view/cdc/249416/cdc_249416_DS1.pdf
• File Type:
  [PDF - 303.21 KB ]