Hypothetical exposure limits for oil-based metalworking fluids and cardiovascular mortality in a cohort of autoworkers: structural accelerated failure time models in a public health framework

Details

• Personal Author:
  Eisen EA ; Peters A ; Picciotto S
• Description:
  Occupational exposure to aerosolized particles of oil-based metalworking fluid was recently linked to deaths from ischemic heart disease. The current recommended exposure limits might be insufficient. Studying cardiovascular mortality is challenging because symptoms can induce sicker workers to reduce their exposure, causing healthy-worker survivor bias. G-estimation of accelerated failure time models reduces this bias and permits comparison of multiple exposure interventions. Michigan autoworkers from the United AutoWorkers-General Motors cohort (n = 38,666) were followed from 1941 through 1994. Separate binary variables indicated whether annual exposure exceeded a series of potential limits. Separate g-estimation analyses for each limit yielded the total number of life-years that could have been saved among persons who died from specific cardiovascular causes by enforcing that exposure limit. Banning oil-based fluids would have saved an estimated 4,003 (95% confidence interval: 2,200, 5,807) life-years among those who died of ischemic heart disease. Estimates for cardiovascular disease overall, acute myocardial infarction, and cerebrovascular disease were 3,500 (95% confidence interval: 1,350, 5,651), 2,932 (95% confidence interval: 1,587, 4,277), and 917 (95% confidence interval: -80, 1,913) life-years, respectively. A limit of 0.01 mg/m(3) would have had a similar impact on cerebrovascular disease but one only half as great on ischemic heart disease. Analyses suggest that limiting exposure to metalworking fluids could have saved many life-years lost to cardiovascular diseases in this cohort. [Description provided by NIOSH]
• Subjects:
  Aerosols Automobiles Cardiovascular Diseases Cardiovascular System Epidemiology Metals Morbidity Mortality Occupational Health Particulate Matter Risk Assessment Risk Factors Safety Workplace

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• Keywords:
  Aerosol-particles Author Keywords: Cardiovascular Mortality Automotive-industry Cardiovascular-disease Cardiovascular-system-disease Cardiovascular-system-disorders Epidemiologic Methods Exposure-levels Healthy Worker Effect Heart Metalworking-fluids Morbidity-rates Mortality-rates Occupational Exposures Oils Particulate Matter Particulates Risk-factors Statistical-analysis Work-environment Workers

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  181
• Issue:
  8
• NIOSHTIC Number:
  nn:20046321
• Citation:
  Am J Epidemiol 2015 Apr; 181(8):563-570
• Contact Point Address:
  Dr. Sally Picciotto, Environmental Health Sciences, UC Berkeley School of Public Health, 50 University Hall, Berkeley, CA 94720-7360
• Email:
  sallypicciotto@berkeley.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of California - Berkeley
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20141231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5321c2e790a80706f0a7b1ef1672d3543819cbf11d55d87a3d7d298353ef9244a5e600c959dd67542377c532c4a3f9154ed722dff05f95f446ad3aa6d25bbc2
• Download URL:
  https://stacks.cdc.gov/view/cdc/201418/cdc_201418_DS1.pdf
• File Type:
  [PDF - 236.11 KB ]