The Short-Term Association of Selected Components of Fine Particulate Matter and Mortality in the Denver Aerosol Sources and Health (DASH) Study

Details

• Personal Author:
  Dutton SJ ; Hannigan MP ; Kim S-Y ; Milford JB ; Miller SL ; Peel JL ; Sheppard L ; Vedal S
• Description:
  Background: Associations of short-term exposure to fine particulate matter (PM2.5) with daily mortality may be due to specific PM2.5 chemical components. Daily concentrations of PM2.5 components were measured over five years in Denver to investigate whether specific PM2.5 components are associated with daily mortality. Methods: Daily counts of total and cause-specific deaths were obtained for the 5-county Denver metropolitan region from 2003 through 2007. Daily 24-hour concentrations of PM2.5, elemental carbon (EC), organic carbon (OC), sulfate and nitrate were measured at a central residential monitoring site. Using generalized additive models, we estimated relative risks (RRs) of daily death counts for daily PM2.5 and four PM2.5 component concentrations at single and distributed lags between the current and three previous days, while controlling for longer-term time trend and meteorology. Results: RR of total non-accidental mortality for an inter-quartile increase of 4.55 ug/m3 in PM2.5 distributed over 4 days was 1.012 (95 % confidence interval: 0.999, 1.025); RRs for EC and OC were larger (1.024 [1.005, 1.043] and 1.020 [1.000, 1.040] for 0.33 and 1.67 ug/m3 increases, respectively) than those for sulfate and nitrate. We generally did not observe associations with cardiovascular and respiratory mortality except for associations with ischemic heart disease mortality at lags 3 and 0-3 depending on the component. In addition, there were associations with cancer mortality, particularly for EC and OC, possibly reflecting advanced deaths of a frail population. Conclusions: PM2.5 components possibly from combustion-related sources are more strongly associated with daily mortality than are secondary inorganic aerosols. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollution Environmental Monitoring Epidemiology Mortality Occupational Health Particulate Matter Risk Assessment Risk Factors Safety
• Keywords:
  Air Pollution Air Sampling Author Keywords: Chemical Components Combustion Gases Fine Particulate Matter Mortality Rates Particulates Risk Factors Time-series Study
• ISSN:
  1476-069X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; North Carolina ; OSHA Region 10 ; OSHA Region 4 ; OSHA Region 8 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  49
• Volume:
  14
• NIOSHTIC Number:
  nn:20054820
• Citation:
  Environ Health 2015 Jun; 14:49
• Contact Point Address:
  Sun-Young Kim, Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA, USA
• Email:
  puha0@uw.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health: A Global Access Science Source
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ff06e2ceae3f6a9f591ffb4893bb4a22bb7539b8ce7814c0c3c935cac62804473245e88bce2e84739fd263207ce59e5f85b54e171aa6a4d9bd96470c5cead017
• Download URL:
  https://stacks.cdc.gov/view/cdc/217242/cdc_217242_DS1.pdf
• File Type:
  [PDF - 1.50 MB ]