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IL-6 negatively regulates IL-22Ra expression on epidermal keratinocytes: implications for irritant contact dermatitis.

File Language:
English


Details

  • Personal Author:
  • Description:
    Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Ra axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown. Using a chemical model of ICD, it was observed that mice with a keratinocyte-specific knockout of IL-6Ra (IL-6Radeltaker) presented with increased inflammation and IL-22Ra and IL-22 protein expression relative to WT following irritant exposure, indicating that IL-6Ra deficiency in epidermal keratinocytes leads to the upregulation of IL-22Ra and its ligand during ICD. Furthermore, it was shown that IL-6 negatively regulates the expression of IL-22Ra on epidermal keratinocytes. This effect is functional as the effects of IL-22 on keratinocyte proliferation and differentiation were markedly reduced when keratinocytes were pretreated with IL-6 prior to IL-22 treatment. These results show that IL-6 modulates the IL-22/IL-22Ra axis in the skin and suggest that this occurrence may be associated with the increased epidermal hyperplasia and exacerbated inflammatory response observed in IL-6Radeltaker mice during ICD. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    2314-7156
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    2019
  • NIOSHTIC Number:
    nn:20065172
  • Citation:
    J Immunol Res 2019 Oct; 2019:6276254
  • Contact Point Address:
    Randle M. Gallucci, Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, 1110 N. Stonewall Avenue, Oklahoma City, OK 73117, USA
  • Email:
    randy-gallucci@ouhsc.edu
  • Federal Fiscal Year:
    2020
  • Performing Organization:
    University of Oklahoma Health Sciences Center, Oklahoma City
  • Peer Reviewed:
    True
  • Start Date:
    20130901
  • Source Full Name:
    Journal of Immunology Research
  • End Date:
    20180831
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:fe3c53c492b714caf35c38f07f419c407a1f793555b059a7386c2ad8d25d90c68ba116be0b902c40f4e3ab3eafb6757d4f91acc3c25ab5c9f47812075ba0254e
  • Download URL:
  • File Type:
    Filetype[PDF - 1.16 MB ]
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