Etiology of lipid-laden macrophages in the lung.

Details

• Personal Author:
  Gow AJ ; Lee SJ ; Smith LC ; Stevenson ER ; Wilkinson ML
• Description:
  Uniquely positioned as sentinel cells constantly exposed to the environment, pulmonary macrophages are vital for the maintenance of the lung lining. These cells are responsible for the clearance of xenobiotics, pathogen detection and clearance, and homeostatic functions such as surfactant recycling. Among the spectrum of phenotypes that may be expressed by macrophages in the lung, the pulmonary lipid-laden phenotype is less commonly studied in comparison to its circulatory counterpart, the atherosclerotic lesion-associated foam cell, or the acutely activated inflammatory macrophage. Herein, we propose that lipid-laden macrophage formation in the lung is governed by lipid acquisition, storage, metabolism, and export processes. The cellular balance of these four processes is critical to the maintenance of homeostasis and the prevention of aberrant signaling that may contribute to lung pathologies. This review aims to examine mechanisms and signaling pathways that are involved in lipid-laden macrophage formation and the potential consequences of this phenotype in the lung. [Description provided by NIOSH]
• Subjects:
  Blood Immune System Lipids Lung Macrophages Occupational Health Pathology Respiratory System Safety
• Keywords:
  Author Keywords: Foam Cell; Immunometabolism; Inflammation; Lipid; Lung; Macrophage Etiology; Lipids; Macrophages; Lung; Immune Reaction; Immunology; Signaling Pathways; Pathology;
• ISSN:
  1567-5769
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; New Jersey ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  123
• NIOSHTIC Number:
  nn:20068521
• Citation:
  Int Immunopharmacol 2023 Oct; 123:110719
• Contact Point Address:
  A.J. Gow, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States
• Federal Fiscal Year:
  2024
• Performing Organization:
  RBHS-Robert Wood Johnson Medical School, Piscataway, New Jersey
• Peer Reviewed:
  True
• Start Date:
  20210701
• Source Full Name:
  International Immunopharmacology
• End Date:
  20240630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248305/cdc_248305_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]